Document Detail

Right ventricular function in chronically anemic fetal lambs.
MedLine Citation:
PMID:  8623858     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine whether the increase in extravascular fluid in chronic fetal anemia occurs either because of heart failure or despite successful cardiac adaptation. STUDY DESIGN: Right ventricular function curves were obtained in five ovine fetuses at the start, midpoint, and end of 5 to 8 days of anemia induced by isovolemic daily hemorrhage. Least-squares fit of the ascending and plateau lines of stroke volume versus right atrial pressure were used to establish breakpoints (intersection of the ascending and plateau lines), which were compared by analysis of variance for repeated measures. Myocardial blood flow was measured by microspheres. RESULTS: Carotid arterial oxygen content was reduced from 7.0 +/- 0.3 to 2.1 +/- 0.1 ml/dl and the hematocrit from 29% +/- 1.8% to 13% +/- 0.6%. Breakpoint analysis of function curves showed that although right atrial pressure remained unchanged (3.4 +/- 0.7 and 3.6 +/- 0.6 mm Hg) stroke volume increased from 1.03 +/- 0.14 to 1.62 +/- 0.25 ml/kg. Both right and left ventricular coronary blood flow were increased, 1351 +/- 313 and 1166 +/- 264 ml/min per 100 gm. Excess fluid was present in abdomen and chest of most animals at autopsy. CONCLUSION: Tissue edema during severe anemia occurs despite normal right atrial pressure, increased stroke volume, and markedly increased coronary blood flow, markers of successful cardiac adaptation.
L E Davis; A R Hohimer; G D Giraud; M D Reller; M J Morton
Related Documents :
21372308 - Safety and tolerability of early noninvasive ventilatory correction using bilevel posit...
10096978 - Ischemic preconditioning does not acutely improve load-insensitive parameters of contra...
8315518 - Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats.
15073388 - Elevated pulse pressure during the acute period of ischemic stroke is associated with p...
22518828 - Absence of inspiratory laryngeal constrictor muscle activity during nasal neurally adju...
10226238 - Predictive power of screening blood pressure, ambulatory blood pressure and blood press...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  174     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-06-17     Completed Date:  1996-06-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1289-94     Citation Subset:  AIM; IM    
Department of Obstetrics, Pediatrics (Cardiology), Oregon Health Sciences University, Portland 97201-3098, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anemia / etiology,  physiopathology*
Carotid Arteries / embryology
Coronary Circulation
Edema / etiology
Fetal Diseases / physiopathology*
Heart / embryology
Oxygen / blood
Stroke Volume
Ventricular Function, Right*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synchronization of the factors critical for diabetic teratogenesis: an in vitro model.
Next Document:  Improved intrapartum surveillance with PR interval analysis of the fetal electrocardiogram: a random...