| Right ventricular function in adult patients with Eisenmenger physiology: insights from quantitative echocardiography. | |
| | |
MedLine Citation:
|
PMID: 20849481 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
BACKGROUND: The favorable outcomes of Eisenmenger syndrome (ES) relative to other forms of pulmonary arterial hypertension (PAH) have been partially attributed to a unique adaptation of the right ventricle (RV). However, conventional measures of RV function may not adequately express this adaptation. METHODS: We studied 23 patients with ES (age 43 ± 17 years, 16 women, pulmonary artery systolic pressure [PASP] 93 ± 26 mmHg), 25 patients with PAH (age 44 ± 13 years, 17 women, PASP 92 ± 19 mmHg), and 25 subjects without known structural disease (age 45 ± 16 years, 17 women). We evaluated long- and short-axis function of the RV with two-dimensional strain and anatomical M-mode echocardiography, respectively. RESULTS: Long-axis function of the RV was comparable between patients with ES and PAH although depressed relative to controls (global strain, -15.6 ± 4.7, -14.9 ± 4.3, and -22.4 ± 2.8%, respectively, P < 0.001; global RV systolic strain rate, -0.77 ± 0.26, -0.84 ± 0.24, and -1.11 ± 0.21 1/sec, respectively, P < 0.001). However, short-axis RV function was significantly better in patients with ES versus those with PAH and preserved relative to controls (RV fractional shortening by anatomical M-mode, median [interquartile range], 21%[14-33%], 14%[10-16%], and 26%[22-36%], respectively, P = 0.002 for ES vs. PAH, P = 0.09 for ES vs. controls). This differential was not reflected in conventional measures of RV function (fractional area change, 32 ± 10 vs. 29 ± 8% in ES and PAH, respectively, P = 0.26). CONCLUSION: In patients with ES, the RV is characterized by preserved short-axis function, despite a depressed long-axis function. Thus, conventional assessment of RV function might not be suitable for patients with ES. |
| | |
Authors:
|
Andreas P Kalogeropoulos; William L Border; Vasiliki V Georgiopoulou; Maria A Pernetz; Sharon Howell; Michael McConnell; Stamatios Lerakis; Javed Butler; Wendy M Book; Randolph P Martin |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Echocardiography (Mount Kisco, N.Y.) Volume: 27 ISSN: 1540-8175 ISO Abbreviation: Echocardiography Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-09-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
|
Languages: eng Pagination: 937-45 Citation Subset: IM |
Copyright Information:
|
© 2010, Wiley Periodicals, Inc. |
Affiliation:
|
Division of Cardiology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30345, USA. a_kalogero@bellsouth.net |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A simplified echocardiographic measurements of direct effects of restrictive annuloplasty on mitral ...
Next Document: New, simple echocardiographic indexes for the estimation of filling pressure in patients with cardia...