| Right ventricular function: a comparison between blood and crystalloid cardioplegia. | |
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MedLine Citation:
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PMID: 3541813 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood cardioplegia resulted in better left ventricular (LV) function than crystalloid cardioplegia after elective coronary artery bypass operations. However, most methods of cardioplegic delivery may not adequately cool and protect the right ventricle, and right ventricular (RV) dysfunction may limit hemodynamic recovery. Therefore, RV and LV temperatures were measured intraoperatively and RV and LV function were evaluated postoperatively in 80 patients with double-vessel or triple-vessel coronary artery disease who were randomized to receive either blood cardioplegia or crystalloid cardioplegia. Myocardial performance, systolic function, and diastolic function were assessed with nuclear ventriculography by evaluating the response to volume loading. Preoperatively the groups were similar. Intraoperatively, blood cardioplegia resulted in significantly warmer LV and RV temperatures (left ventricle: 15.5 degrees +/- 0.2 degrees C with blood cardioplegia and 12.6 degrees +/- 0.3 degrees C with crystalloid cardioplegia [p less than .0001]; right ventricle: 18.3 degrees +/- 0.3 degrees C with blood cardioplegia and 15.1 degrees +/- 0.3 degrees C with crystalloid cardioplegia [p less than .0001]). Postoperatively, blood cardioplegia resulted in better LV performance (higher LV stroke work index at a similar LV end-diastolic volume index [EDVI]) (p = .01), better LV systolic function (similar systolic blood pressures at smaller LV end-systolic volume indexes [ESVI]), (p = .04), and improved LV diastolic function (lower left atrial pressures at similar LVEDVIs) (p = .03).(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J C Mullen; S E Fremes; R D Weisel; G T Christakis; J Ivanov; M M Madonik; S Houle; P R McLaughlin |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Annals of thoracic surgery Volume: 43 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1987 Jan |
Date Detail:
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Created Date: 1987-02-11 Completed Date: 1987-02-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 17-24 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure Body Temperature Cardiopulmonary Bypass Clinical Trials as Topic Female Heart Arrest, Induced / methods* Hemodynamics* Humans Intensive Care Units / methods Male Mathematics Middle Aged Myocardial Revascularization* Random Allocation Stroke Volume Ventricular Function |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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