Document Detail

Right ventricular ejection fraction during orthotopic liver transplantation: does anesthetic technique make a difference?
MedLine Citation:
PMID:  20381292     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The objective of this study is to evaluate the right ventricular ejection fraction (RVEF) during orthotopic liver transplantation (OLT) under 2 different anesthetic regimens: propofol vs isoflurane anesthesia.
METHODS: We retrospectively analyzed the hemodynamic data of 25 (n = 25) patients who underwent OLT during the last year (2008). All patients were monitored with a modified pulmonary artery catheter, which continuously measured the RVEF. Anesthetic technique consisted of either isoflurane or total intravenous anesthesia with propofol. Surgical technique was similar between groups.
RESULTS: Ten (n = 10) patients comprised the isoflurane group (I), whereas 15 (n = 15) patients received propofol anesthesia (P). The RVEF was not significantly different between groups (I vs P, baseline: 41% ± 9% vs 40% ± 6%; anhepatic phase: 36% ± 8% vs 35% ± 6%; postreperfusion: 41% ± 6% vs 41% ± 8%; P = not significant).
CONCLUSIONS: The choice between propofol and isoflurane seems to have minimal influence on the RVEF during OLT, which followed similar trends regardless of the anesthetic technique.
Glauber Gouvêa; Rodrigo Diaz; Lúcio Auler; Renato Toledo; José Manoel Martinho
Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2010-04-08
Journal Detail:
Title:  Journal of critical care     Volume:  25     ISSN:  1557-8615     ISO Abbreviation:  J Crit Care     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-26     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610642     Medline TA:  J Crit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  657.e1-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Liver Transplantation Unit, Department of Anesthesiology, Bonsucesso General Hospital, Rio de Janeiro 21041-030, Brazil.
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MeSH Terms
Anesthesia / methods*
Anesthesia, Intravenous
Isoflurane / pharmacology*
Liver Cirrhosis / surgery
Liver Transplantation / physiology*
Middle Aged
Propofol / pharmacology*
Retrospective Studies
Ventricular Function, Right / drug effects*
Reg. No./Substance:
2078-54-8/Propofol; 26675-46-7/Isoflurane

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