Document Detail

Right ventricular dysfunction in obstructive sleep apnoea: reversal with nasal continuous positive airway pressure.
MedLine Citation:
PMID:  8793456     Owner:  NLM     Status:  MEDLINE    
The incidence and pathogenesis of right ventricular dysfunction in obstructive sleep apnoea (OSA) remains controversial. Using nuclear ventriculography, the prevalence of right ventricular dysfunction (RVD) was therefore determined in obese patients with OSA, as well as their clinical characteristics, arterial blood gas values, spirometry and sleep parameters. The reversibility of RVD was evaluated after long-term use of nasal continuous positive airway pressure (nCPAP). We studied 112 obese patients with OSA by nuclear ventriculography, 35 with RVD (Group 1), 77 without RVD (Group 2), and 14 patients without OSA as controls (Group 3). Repeat nuclear ventriculography was performed in seven patients who used nCPAP nightly for 6-24 months. The mean right ventricular ejection fractions (RVEF) were 31%, 47% and 44% in Groups 1, 2 and 3, respectively. Group 1 also had a lower left ventricular ejection fraction (LVEF) of 55 vs 63% in Group 2. The OSA groups did not differ in mean spirometric or arterial blood gas values. Group 1 had a lower mean nocturnal arterial oxygen saturation (Sa,O2) of 82 vs 87% in Group 2, and a longer apnoea duration of 22.3 vs 19.2 s. All but two patients in Group 1 had either awake alveolar hypoventilation or an apnoea + hypopnoea index > 40 disordered breathing events.h-1. Repeat nuclear ventriculography after nCPAP revealed an increase in RVEF from 30 to 39%. In conclusion, right ventricular dysfunction is common in obstructive sleep apnoea, but it is reversible with nasal continuous positive airway pressure treatment and appears to be related to nocturnal oxygen desaturation.
J Nahmias; R Lao; M Karetzky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  9     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-06     Completed Date:  1996-12-06     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  945-51     Citation Subset:  IM    
Newark Beth Israel Medical Center, New Jersey 07112, USA.
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MeSH Terms
Blood Gas Analysis
Middle Aged
Positive-Pressure Respiration* / methods
Prospective Studies
Radionuclide Ventriculography
Respiratory Function Tests
Risk Factors
Sex Distribution
Sleep Apnea Syndromes / complications*,  therapy
Ventricular Dysfunction, Right / epidemiology*,  etiology*,  radionuclide imaging

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