| Right ventricular dysfunction in adolescents with mild cystic fibrosis. | |
| | |
MedLine Citation:
|
PMID: 22483972 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: In cystic fibrosis (CF) patients the right ventricle (RV) suffers a progressive deterioration, but it is not clear when these changes begin. The aim of this study was to analyze the RV function in CF patients with mild respiratory disease. METHODS: Color-Doppler-Echocardiographic studies were prospectively performed in CF adolescent patients and an age-matched control group. Findings were correlated with pulmonary function tests (PFT), genotype, chronic bacterial colonization, pancreatic status and clinical scores. Only patients with mild CF were selected. RESULTS: Thirty seven CF patients and 40 healthy controls were recruited. In CF patients all echocardiographic parameters were abnormal compared to controls. Doppler analysis showed slightly elevated pulmonary artery pressure values, and abnormal relaxation and systolic function for all indexes. No correlation was found with any of the features studied. CONCLUSIONS: In CF patients, abnormalities in the structure and function of the RV may be present at early stages of the disease. These abnormalities are subclinical and do not correlate with clinical scores, PFT, genotype, chronic bacterial colonization or pancreatic insufficiency. |
| | |
Authors:
|
Antonio Baño-Rodrigo; Antonio Salcedo-Posadas; Jose R Villa-Asensi; Amalia Tamariz-Martel; Alejandro Lopez-Neyra; Elena Blanco-Iglesias |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-5 |
Journal Detail:
|
Title: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society Volume: - ISSN: 1873-5010 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101128966 Medline TA: J Cyst Fibros Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. |
Affiliation:
|
Department of Cardiology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain; Department of Pediatrics, Universidad Autonoma de Madrid, Madrid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) in Chinese patients with...
Next Document: When fear forms memories: Threat of shock and brain potentials during encoding and recognition.