Document Detail

Right ventricular dysfunction in adolescents with mild cystic fibrosis.
MedLine Citation:
PMID:  22483972     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In cystic fibrosis (CF) patients the right ventricle (RV) suffers a progressive deterioration, but it is not clear when these changes begin. The aim of this study was to analyze the RV function in CF patients with mild respiratory disease.
METHODS: Color-Doppler-Echocardiographic studies were prospectively performed in CF adolescent patients and an age-matched control group. Findings were correlated with pulmonary function tests (PFT), genotype, chronic bacterial colonization, pancreatic status and clinical scores. Only patients with mild CF were selected.
RESULTS: Thirty seven CF patients and 40 healthy controls were recruited. In CF patients all echocardiographic parameters were abnormal compared to controls. Doppler analysis showed slightly elevated pulmonary artery pressure values, and abnormal relaxation and systolic function for all indexes. No correlation was found with any of the features studied.
CONCLUSIONS: In CF patients, abnormalities in the structure and function of the RV may be present at early stages of the disease. These abnormalities are subclinical and do not correlate with clinical scores, PFT, genotype, chronic bacterial colonization or pancreatic insufficiency.
Antonio Baño-Rodrigo; Antonio Salcedo-Posadas; Jose R Villa-Asensi; Amalia Tamariz-Martel; Alejandro Lopez-Neyra; Elena Blanco-Iglesias
Publication Detail:
Type:  Journal Article     Date:  2012-04-06
Journal Detail:
Title:  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society     Volume:  11     ISSN:  1873-5010     ISO Abbreviation:  J. Cyst. Fibros.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-19     Completed Date:  2012-10-25     Revised Date:  2013-07-16    
Medline Journal Info:
Nlm Unique ID:  101128966     Medline TA:  J Cyst Fibros     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  274-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Department of Cardiology, Hospital Infantil Universitario Niño Jesus, Madrid, Spain.
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MeSH Terms
Cystic Fibrosis / complications*,  genetics
Cystic Fibrosis Transmembrane Conductance Regulator / genetics
Echocardiography, Doppler, Color
Heart Ventricles / pathology,  physiopathology
Myocardial Contraction / physiology
Prospective Studies
Pulmonary Heart Disease / etiology,  physiopathology,  ultrasonography
Respiratory Function Tests
Severity of Illness Index*
Tricuspid Valve / physiology
Ventricular Dysfunction, Right / etiology*,  physiopathology,  ultrasonography*
Reg. No./Substance:
0/CFTR protein, human; 126880-72-6/Cystic Fibrosis Transmembrane Conductance Regulator
Comment In:
J Cyst Fibros. 2013 Jul;12(4):417   [PMID:  23146659 ]

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