| Right ventricular dysfunction is associated with chronic kidney disease and predicts survival in patients with chronic systolic heart failure. | |
| | |
MedLine Citation:
|
PMID: 22357576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: Chronic kidney disease (CKD) and right ventricular (RV) dysfunction are important predictors of prognosis in heart failure (HF). We investigated the relationship between RV dysfunction and CKD in outpatients with chronic systolic HF, an association which remains poorly defined. METHODS AND RESULTS: Outpatients (n = 373) with chronic HF and left ventricular ejection fraction (LVEF) ≤45% underwent clinical and echo-Doppler evaluations and were followed up for 31 ± 24 months. Tricuspid annular plane systolic excursion (TAPSE) assessed RV dysfunction. The estimated glomerular filtration rate (GFR) was measured by the simplified Modification of Diet in Renal Disease (MDRD) formula. Correlation analysis was used to characterize the association between TAPSE and estimated GFR. Odds ratios (ORs) for CKD and hazard ratios (HRs) for all-cause mortality were assessed using multivariable logistic or proportional hazards regression models. TAPSE and estimated GFR were significantly correlated (r = 0.38, P < 0.0001). TAPSE ≤14 mm was associated with elevated estimated right atrial pressure and N-terminal pro brain natriuretic peptide levels. TAPSE ≤14 mm increased the odds of estimated GFR <60 mL/min/1.73 m(2), OR [95% confidence interval (CI)] = 2.51(1.44-4.39), P < 0.0001 and predicted all-cause mortality, HR (95% CI) = 1.80 (1.20-2.71) after multivariable adjustment. CONCLUSIONS: Right ventricular dysfunction is cross-sectionally associated with CKD and prospectively predicts survival in outpatients with chronic systolic HF. These data suggest RV dysfunction to be one of the possible mechanistic links between HF and CKD. |
| | |
Authors:
|
Frank L Dini; Ryan T Demmer; Anca Simioniuc; Doralisa Morrone; Francesca Donati; Giacinta Guarini; Enrico Orsini; Paolo Caravelli; Mario Marzilli; Paolo C Colombo |
Related Documents
:
|
2297836 - Two-dimensional echocardiographic determination of ventricular volumes in the fetal hea... 7426186 - Serial measurements of left ventricular dimensions by echocardiography. assessment of w... 12032476 - Comparison between ectb and qgs for assessment of left ventricular function from gated ... 19641716 - Evaluation of cardiac resynchronization therapy in drug-resistant idiopathic dilated ca... 23288896 - Cardiac risk assessment before non-cardiac surgery. 16547206 - The logistic euroscore in cardiac surgery: how well does it predict operative risk? |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Validation Studies |
Journal Detail:
|
Title: European journal of heart failure Volume: 14 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2012 Mar |
Date Detail:
|
Created Date: 2012-02-23 Completed Date: 2012-06-19 Revised Date: 2013-04-15 |
Medline Journal Info:
|
Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 287-94 Citation Subset: IM |
Affiliation:
|
Cardiac, Thoracic and Vascular Department, University of Pisa, Via Paradisa 2, Pisa, Italy. f.dini@ao-pisa.toscana.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Analysis of Variance Confidence Intervals Echocardiography Female Glomerular Filtration Rate Heart Failure, Systolic / mortality, pathology*, ultrasonography Humans Kidney Failure, Chronic / mortality, pathology*, ultrasonography Male Middle Aged Odds Ratio Outpatients Prognosis Risk Factors Statistics as Topic Stroke Volume United States Ventricular Dysfunction, Right / mortality, pathology*, ultrasonography Ventricular Function, Left |
| Grant Support | |
ID/Acronym/Agency:
|
DE018739/DE/NIDCR NIH HHS; R01 HL092144/HL/NHLBI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Criminality in men with Klinefelter's syndrome and XYY syndrome: a cohort study.
Next Document: Clinical course and predictive value of liver function tests in patients hospitalized for worsening ...