| Right ventricular dysfunction and B-type natriuretic peptide in asymptomatic patients after repair for tetralogy of Fallot. | |
| | |
MedLine Citation:
|
PMID: 19475443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Early detection of right ventricular (RV) dysfunction is essential in the assessment of patients with repaired tetralogy of Fallot (TOF). This study aimed to assess latent RV dysfunction in asymptomatic patients with TOF and to determine the predictive value of B-type natriuretic peptide (BNP). Pressure-volume loops were recorded for 16 young patients (New York Heart Association class 1 or Ross class 0; median age, 14.2 years) using the conductance catheter technique. All the patients had RV dilation secondary to pulmonary regurgitation after surgical repair of TOF. Indexes of RV function were derived at baseline level and during dobutamine infusion. Contractility was calculated by the slope of the end-systolic pressure-volume relation (ESPVR). An increase in ESPVR during dobutamine infusion was considered to indicate contractile reserve as a marker for latent RV dysfunction. The median ESPVR significantly increased from 0.32 mmHg/ml (0.13-0.72 mmHg/ml) at baseline to 0.57 mmHg/ml (0.24-1.55 mmHg/ml) during dobutamine infusion (p = 0.005). However, for five patients, no relevant increase in contractility was found, indicating impaired RV contractile reserve. There was only a weak inverse correlation between impaired contractile reserve and BNP (r = -0.28). Even asymptomatic patients with only a mildly enlarged right ventricle can have impaired RV function. Early RV dysfunction cannot be predicted accurately with BNP. |
| | |
Authors:
|
Christian Apitz; Ludger Sieverding; Heiner Latus; Anselm Uebing; Stefan Schoof; Michael Hofbeck |
Related Documents
:
|
2884253 - Time-course of changes in cardiac hypertrophy and pressor mechanisms in two-kidney, one... 2476563 - Differential effects of triiodothyronine on rat left and right ventricular function and... 15611363 - Recommendations for blood pressure measurement in humans and experimental animals. part... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-05-28 |
Journal Detail:
|
Title: Pediatric cardiology Volume: 30 ISSN: 1432-1971 ISO Abbreviation: Pediatr Cardiol Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-09-25 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 898-904 Citation Subset: IM |
Affiliation:
|
Division of Pediatric Cardiology, University Children's Hospital, Hoppe-Seyler-Strasse 1, 72076 Tuebingen, Germany. christian.apitz@med.uni-tuebingen.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Biological Markers / blood Child Child, Preschool Female Heart Catheterization Hemodynamics Humans Infant Male Natriuretic Peptide, Brain / blood* Statistics, Nonparametric Tetralogy of Fallot / physiopathology, surgery* Ventricular Dysfunction, Right / blood*, physiopathology |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Complete Mitochondrial Genome Sequence of the Hornwort Megaceros aenigmaticus Shows a Mixed Mode...
Next Document: Seasonal Depth-Related Gradients in Virioplankton: Standing Stock and Relationships with Microbial C...