| Right ventricular distension alters monophasic action potential duration during pulmonary arterial occlusion in anaesthetised lambs: evidence for arrhythmogenic right ventricular mechanoelectrical feedback. | |
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MedLine Citation:
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PMID: 11571494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormal loading and distension of the right ventricle may induce arrhythmia through the process of mechanoelectrical feedback. Nonetheless, the electrophysiological effects of right ventricular distension are ill-defined and the mechanisms which underpin mechanoelectrical feedback in the right ventricle are unknown. We examined the effects of changes in right ventricular load (complete occlusion of both caval veins or the main pulmonary artery) in 14 anaesthetised lambs, instrumented with right ventricular surface electrodes and strain gauges for recording monophasic action potential and segment length, and an integrated conductance and micromanometer-tipped catheter for measurement of right ventricular pressure and volume. Caval occlusion did not alter right ventricular segment length and monophasic action potential duration. By contrast, pulmonary arterial occlusion increased the segment length and decreased the monophasic action potential duration at 25, 50 and 70% repolarisation by 29 +/- 6, 22 +/- 4 and 17 +/- 3 ms, respectively (all P < 0.01). Of the 42 pulmonary arterial occlusions, 38 were associated with early afterdepolarisations (EADs) which increased progressively in magnitude as the occlusion was maintained until, in 32, overt arrhythmia was observed. By contrast, none of the four occlusions in which EADs were not observed resulted in arrhythmia. As a result, the proportion of occlusions which resulted in arrhythmia were greater in those associated with EADs than in those which were not (P = 0.002). Right ventricular distension alters the pattern of repolarisation, precipitates early afterdepolarisations and results in a variety of ventricular arrhythmia, including ventricular tachycardia. |
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Authors:
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G Greve; M J Lab; R Chen; D Barron; P A White; A N Redington; D J Penny |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental physiology Volume: 86 ISSN: 0958-0670 ISO Abbreviation: Exp. Physiol. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-25 Completed Date: 2002-02-19 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9002940 Medline TA: Exp Physiol Country: England |
Other Details:
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Languages: eng Pagination: 651-7 Citation Subset: IM |
Affiliation:
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The National Heart and Lung Institute, Imperial College of Science, Technology and Medicine and The Institute of Child Health, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Arrhythmias, Cardiac / physiopathology* Feedback, Physiological Heart Ventricles / physiopathology Humans Pulmonary Artery / physiology* Sheep Ventricular Dysfunction, Right / physiopathology* Ventricular Function* Ventricular Pressure |
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