Document Detail

Right ventricular diastolic pressure-volume relations and regional dimensions during acute alterations in loading conditions.
MedLine Citation:
PMID:  3370767     Owner:  NLM     Status:  MEDLINE    
Acute pharmacologically mediated parallel shifts in the left ventricular diastolic pressure-volume relation may be due to the restraining effect of the pericardium and/or leftward displacement of the interventricular septum. The existence and cause of this phenomenon in the right ventricle has not been studied in animals or in man. Accordingly, we altered right ventricular pressure with intravenous phenylephrine (0.2 to 0.3 mg) and nitroprusside (0.5 to 1.5 micrograms/kg/min) to achieve three disparate peak right ventricular pressures in nine normal subjects after partial autonomic blockade with atropine (1 mg) and propranolol (0.15 mg/kg). Simultaneous high-fidelity right ventricular pressures and biplane cineventriculographic volumes were acquired during the three resultant loading conditions. Right atrial pacing maintained heart rate constant at each pressure level. Peak right ventricular systolic pressure (23 +/- 3 vs 31 +/- 9 vs 45 +/- 6 mm Hg, all p less than .01) and right ventricular end-diastolic pressure (4 +/- 2 vs 8 +/- 4 vs 11 +/- 3 mm Hg, all p less than .01) were significantly different at low, medium, and high loading conditions, respectively. Right ventricular diastolic pressure-volume relations were, in parallel, shifted upward with altered loading in each patient. This was manifest by an unchanged dynamic chamber stiffness constant and a significant increase in the diastolic pressure volume y intercept at each load (1.98 +/- 2.21 vs 5.33 +/- 5.39 vs 8.51 +/- 3.99 mm Hg, p less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)
L J Dell'Italia; R A Walsh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  77     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-28     Completed Date:  1988-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1276-82     Citation Subset:  AIM; IM    
Department of Medicine, University of Texas Health Science Center, San Antonio 78284.
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MeSH Terms
Angina Pectoris / diagnosis*,  physiopathology
Atropine / diagnostic use
Heart Catheterization
Heart Ventricles / drug effects,  physiopathology,  radiography
Hemodynamics / drug effects
Middle Aged
Nitroprusside / diagnostic use
Phenylephrine / diagnostic use
Propranolol / diagnostic use
Stroke Volume* / drug effects
Grant Support
Reg. No./Substance:
15078-28-1/Nitroprusside; 51-55-8/Atropine; 525-66-6/Propranolol; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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