Document Detail


Right ventricular adaptation and maladaptation in chronic pulmonary arterial hypertension.
MedLine Citation:
PMID:  22548816     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The right ventricle (RV) is not well suited to chronic pressure overload and often fails to adequately compensate. Mechanisms that allow the RV to respond to acute pressure overload often become maladaptive and contribute to its failure, including the effects of pulmonary hypertension on RV myocardial perfusion, the influence of interventricular dependence on RV function, and metabolic shifts in the RV myocardium from fatty acid to glycolysis. Medications to treat pulmonary hypertension have focused on pulmonary vasodilatation. Their effects on RV function may determine their effectiveness. How new medications affect right ventricular performance must be addressed.
Authors:
Stuart Rich
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology clinics     Volume:  30     ISSN:  1558-2264     ISO Abbreviation:  Cardiol Clin     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8300331     Medline TA:  Cardiol Clin     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  257-69     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Medicine, Section of Cardiology, University of Chicago, 5841 South Maryland Avenue, MC 5403; Suite L 08, Chicago, IL 60637, USA.
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