Document Detail

Right-to-left shunting through a patent foramen ovale in right ventricular infarction: improvement of hypoxemia and hemodynamics with inhaled nitric oxide.
MedLine Citation:
PMID:  14507565     Owner:  NLM     Status:  MEDLINE    
Inhaled nitric oxide is a selective pulmonary vasodilator that has been used successfully to treat hemodynamic embarrassment and right-to-left interatrial shunting in acute right heart failure. Previous reports have been in the setting of disorders causing elevated right heart afterload, such as pulmonary embolism, acute respiratory distress syndrome, and chronic obstructive pulmonary disease. Right ventricular infarction is a less common, but important cause of acute right heart failure with which the intensivist should be familiar. We report a patient with right ventricular infarction for whom cardiogenic shock and refractory hypoxemia due to right-to-left interatrial shunting were effectively treated with inhaled nitric oxide. The potential for broader application of inhaled nitric oxide as a therapy for right ventricular infarction is discussed.
Michael B Fessler; John J Lepore; B Taylor Thompson; Marc J Semigran
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  15     ISSN:  0952-8180     ISO Abbreviation:  J Clin Anesth     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-25     Completed Date:  2004-02-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
Cardiology Division, Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114-2696, USA.
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MeSH Terms
Anoxia / drug therapy*,  etiology*
Blood Gas Analysis
Heart Septal Defects, Atrial / complications*,  physiopathology
Hemodynamics / drug effects*
Myocardial Infarction / complications*
Nitric Oxide / administration & dosage,  therapeutic use*
Oxygen Consumption / drug effects
Vasodilator Agents / administration & dosage,  therapeutic use*
Ventricular Dysfunction, Right / complications*,  physiopathology
Grant Support
Reg. No./Substance:
0/Vasodilator Agents; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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