Document Detail


Right-to-left shunt in CADASIL patients: prevalence and correlation with clinical and MRI findings.
MedLine Citation:
PMID:  18451353     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: A high prevalence of right-to-left shunt (RLS) was described in a family of patients with CADASIL, a rare cerebral arteriopathy attributable to Notch3 gene mutations. The aim of this study was to determine the prevalence of RLS in patients with CADASIL and possible relation to clinical phenotype and cerebral MRI lesion load. METHODS: Twenty-three CADASIL patients underwent Transcranial Doppler with gaseous contrast to asses RLS. Correlations between RLS, clinical features, and MRI lesion volume (LV) were determined. RESULTS: Large RLS was diagnosed in 47% of patients. No significant clinical or MRI differences were found between patients with and without RLS. CONCLUSIONS: We found a high prevalence of RLS in our group of CADASIL patients. This may not be a coincidence, but can be rather related to the role of the Notch receptor family in the development of cardiovascular system.
Authors:
Enza Zicari; Rossana Tassi; Maria L Stromillo; Michele Pellegrini; Silvia Bianchi; Gabriele Cevenini; Massimo Gistri; Nicola De Stefano; Antonio Federico; Maria T Dotti
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Publication Detail:
Type:  Letter; Research Support, Non-U.S. Gov't     Date:  2008-05-01
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  39     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-07-23     Revised Date:  2009-07-01    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2155-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain / pathology
CADASIL / epidemiology*,  pathology,  therapy*
Female
Foramen Ovale, Patent / metabolism,  pathology
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Mutation
Phenotype
Prevalence
Receptors, Notch / genetics
Ultrasonography, Doppler / methods
Chemical
Reg. No./Substance:
0/NOTCH3 protein, human; 0/Receptors, Notch
Comments/Corrections
Comment In:
Stroke. 2009 Jul;40(7):e509; author reply e510   [PMID:  19478217 ]
Stroke. 2008 Oct;39(10):e150; author reply e151   [PMID:  18757285 ]

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