| Right-to-left shunt in CADASIL patients: prevalence and correlation with clinical and MRI findings. | |
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MedLine Citation:
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PMID: 18451353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: A high prevalence of right-to-left shunt (RLS) was described in a family of patients with CADASIL, a rare cerebral arteriopathy attributable to Notch3 gene mutations. The aim of this study was to determine the prevalence of RLS in patients with CADASIL and possible relation to clinical phenotype and cerebral MRI lesion load. METHODS: Twenty-three CADASIL patients underwent Transcranial Doppler with gaseous contrast to asses RLS. Correlations between RLS, clinical features, and MRI lesion volume (LV) were determined. RESULTS: Large RLS was diagnosed in 47% of patients. No significant clinical or MRI differences were found between patients with and without RLS. CONCLUSIONS: We found a high prevalence of RLS in our group of CADASIL patients. This may not be a coincidence, but can be rather related to the role of the Notch receptor family in the development of cardiovascular system. |
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Authors:
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Enza Zicari; Rossana Tassi; Maria L Stromillo; Michele Pellegrini; Silvia Bianchi; Gabriele Cevenini; Massimo Gistri; Nicola De Stefano; Antonio Federico; Maria T Dotti |
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Publication Detail:
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Type: Letter; Research Support, Non-U.S. Gov't Date: 2008-05-01 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 39 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-24 Completed Date: 2008-07-23 Revised Date: 2009-07-01 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 2155-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Brain / pathology CADASIL / epidemiology*, pathology, therapy* Female Foramen Ovale, Patent / metabolism, pathology Humans Magnetic Resonance Imaging / methods* Male Middle Aged Mutation Phenotype Prevalence Receptors, Notch / genetics Ultrasonography, Doppler / methods |
| Chemical | |
Reg. No./Substance:
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0/NOTCH3 protein, human; 0/Receptors, Notch |
| Comments/Corrections | |
Comment In:
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Stroke. 2009 Jul;40(7):e509; author reply e510
[PMID:
19478217
]
Stroke. 2008 Oct;39(10):e150; author reply e151 [PMID: 18757285 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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