| Right temporal cerebral dysfunction heralds symptoms of acute mountain sickness. | |
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MedLine Citation:
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PMID: 17345040 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute mountain sickness (AMS) can occur during climbs to high altitudes and may seriously disturb the behavioral and intellectual capacities of susceptible subjects. During a Himalayan expedition 32 mountaineers were examined with electroencephalography (EEG) and transcranial doppler sonography (TCD) to assess relative changes of middle cerebral artery velocity in relation to end-expiratory CO2 (EtCO2), peripheral saturation (SaO2), and symptoms of AMS. We tested the hypothesis that O2 desaturation and EtCO2 changes precede the development of AMS and result in brain dysfunction and compensatory mechanisms which can be measured by EEG and TCD, respectively. Contrary to our hypothesis, we found that subjects who later developed symptoms of AMS between 3,440 m and 5,050 m altitude exhibited an increase of slow cerebral activity in the right temporal region already at 3,440 m. Cerebral blood flow increased in these mountaineers in the right middle cerebral artery at 5,050 m. These findings indicate that regional brain dysfunction, which can be documented by EEG, heralds the appearance of clinical symptoms of AMS. |
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Authors:
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Berend Feddersen; Harald Ausserer; Pritam Neupane; Florian Thanbichler; Antoine Depaulis; Robb Waanders; Soheyl Noachtar |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-07 |
Journal Detail:
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Title: Journal of neurology Volume: 254 ISSN: 0340-5354 ISO Abbreviation: J. Neurol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-12 Completed Date: 2007-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 359-63 Citation Subset: IM |
Affiliation:
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Department of Neurology, Klinikum Grosshadern, University of Munich, Marchioninistr. 15, 81377, Munich, Germany. berend.feddersen@med.uni-muenchen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acclimatization Acute Disease Adult Aged Altitude Altitude Sickness / blood, complications*, pathology*, ultrasonography Brain Mapping Carbon Dioxide / blood Cerebrovascular Circulation / physiology* Electroencephalography / methods Female Functional Laterality / physiology* Humans Male Middle Aged Mountaineering Oxygen / blood Respiratory Function Tests Statistics, Nonparametric Temporal Lobe / physiopathology*, ultrasonography Ultrasonography, Doppler, Transcranial / methods |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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