Document Detail


Right-sided vagus nerve stimulation reduces generalized seizure severity in rats as effectively as left-sided.
MedLine Citation:
PMID:  14529948     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As currently utilized, vagus nerve stimulation (VNS) is applied to the cervical trunk of the left vagus nerve to suppress seizures clinically. Demonstration that VNS can also reduce seizure severity when electrodes are placed on the right cervical vagus nerve in rats would provide empirical evidence that the antiepileptic effects of VNS are not an exclusive property of the left vagus nerve. Rats were implanted with a custom cuff electrode on either the left or right cervical vagus nerve. Two days later, continuous VNS was begun in half the rats with left-sided and half with right-sided electrodes. The remaining rats were connected to the stimulator, but did not receive VNS. After 30s, pentylenetetrazole (PTZ) was administered systemically and seizures were rated by a blinded observer. The PTZ test was repeated two days later, with VNS administered to the previously unstimulated rats, while the others received no stimulation. VNS significantly reduced the severity of PTZ-induced seizures in rats regardless of the side of stimulation as compared to their no-VNS (control condition) seizure severity. No significant differences in efficacy existed based on the side of stimulation. These results indicate that right-sided VNS in rats is just as effective as left-sided VNS, suggesting that fibers necessary for seizure suppression are not unique to the left vagus nerve.
Authors:
Scott E Krahl; Shayani S Senanayake; Adrian Handforth
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Epilepsy research     Volume:  56     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-07     Completed Date:  2004-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Affiliation:
Neurology Service, VA Greater Los Angeles Healthcare System, and Division of Neurosurgery, University of California, Los Angeles, USA. scott.krahl@med.va.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Electric Stimulation Therapy / methods*
Electrodes
Epilepsy, Generalized / chemically induced,  therapy*
Functional Laterality / physiology*,  radiation effects
Pentylenetetrazole
Rats
Rats, Sprague-Dawley
Vagus Nerve / physiology,  radiation effects*
Chemical
Reg. No./Substance:
54-95-5/Pentylenetetrazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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