Document Detail

Right and left ventricular performance 10 years after Mustard repair of transposition of the great arteries.
MedLine Citation:
PMID:  8059729     Owner:  NLM     Status:  MEDLINE    
Twenty-two late survivors of Mustard repair of transposition of the great arteries underwent treadmill exercise testing to assess exercise endurance, and radionuclide cineangiography to measure rest and exercise right ventricular (RV) and left ventricular (LV) ejection fraction (EF). Mean age at Mustard repair was 1.8 +/- 2.4 years and at initial exercise study 14.1 +/- 4.5 years. All patients were asymptomatic at study entry. Treadmill endurance time (9 to 12 minutes) was within the normal range for age in 18 of 20 patients. LVEF and RVEF at rest were within normal limits (55 +/- 8% and 52 +/- 9%, respectively). All LVEFs and RVEFs during exercise were also within the normal range (64 +/- 8% and 57 +/- 9%, respectively). However, the magnitude of increase in EF (rest to exercise) was subnormal for the right ventricle in 7 patients and for the left ventricle in 2 patients. Exercise RVEF was higher in patients with simple transposition who underwent repair at < 1 year of age than in those who underwent operation at age > 1 year (62 +/- 10% vs 52 +/- 7%). Serial study in 6 patients revealed no change in average RVEF or LVEF after an average interval of 4.4 years. One patient with complex transposition subsequently developed refractory congestive heart failure requiring cardiac transplantation. It is concluded that exercise endurance and LVEF and RVEF at rest and exercise are generally well preserved up to 19 years after Mustard repair, particularly in cases of simple transposition of the great arteries repaired before 1 year of age.
C Hochreiter; M S Snyder; J S Borer; M A Engle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  74     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-15     Completed Date:  1994-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  478-82     Citation Subset:  AIM; IM    
Department of Medicine, Cornell University Medical College, New York, New York 10021.
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MeSH Terms
Blood Pressure / physiology
Child, Preschool
Exercise Test
Heart Rate / physiology
Time Factors
Transposition of Great Vessels / physiopathology*,  surgery*
Ventricular Function, Left / physiology*
Ventricular Function, Right / physiology*

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