Document Detail


Right and left ventricular oxygen metabolism in open-chest dogs.
MedLine Citation:
PMID:  7137369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A comparison of blood flow and myocardial O2 consumption (MVO2) in the right and left ventricles was made in 21 open-chest dogs. Simultaneous measurements were made of left anterior descending (LAD) and right coronary arterial blood flow and of O2 saturation in the coronary sinus and in from one to four anterior cardiac veins. Blood flow was greater in the LAD than in the right coronary artery, 87 +/- 5 vs. 46 +/- 3 ml.min-1.100 g-1. Similarly, the O2 saturation was 51 +/- 3% in the anterior cardiac veins and 40 +/- 1% in the coronary sinus. In a subset of seven dogs, the O2 saturation in blood from anterior cardiac veins varied substantially from vein to vein. The mean MVO2 was greater for the left than for the right ventricle, 8.6 +/- 1.4 vs. 4.0 +/- 0.3 ml O2.min-1,100 g-1. Increases in LAD flow with no increase in O2 extraction accounted for enhanced MVO2 of the left ventricle due to pacing, isoproterenol, or methoxamine. In contrast, pacing, isoproterenol, or constriction of the pulmonary artery increased MVO2 of the right ventricle by both augmented O2 extraction and a rise in right coronary blood flow. We conclude that right coronary arterial blood flow is lower per 100 g tissue and is less dependent on MVO2 than is LAD blood flow. The heterogeneity of O2 saturation in anterior cardiac veins suggests that regional differences in MVO2 may exist.
Authors:
S Kusachi; O Nishiyama; K Yasuhara; D Saito; S Haraoka; H Nagashima
Related Documents :
2540619 - The role of coronary alpha 1-adrenoceptors of the dog heart in dopamine-induced cardios...
2265649 - Acute hypercalcemia and increased work load in canine transplanted heart. coronary bloo...
18223669 - Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: bene...
7818109 - Does nitrous oxide affect coronary microcirculation? an intravital microscopic study in...
7930229 - Effect of l-arginine on acetylcholine-induced endothelium-dependent vasodilation differ...
1463369 - Tolerance to the increase in coronary blood flow induced by krn2391.
2873279 - Dipsticks for determining abo blood groups.
24014969 - Staphylococcal blood stream infections: epidemiology, resistance pattern and outcome at...
11717019 - Off-pump coronary bypass surgery causes less immediate postoperative coronary endotheli...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  243     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1982-12-18     Completed Date:  1982-12-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H761-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Coronary Vessels / physiology
Dogs
Female
Heart / drug effects
Heart Rate / drug effects
Heart Ventricles / metabolism
Isoproterenol / pharmacology
Male
Methoxamine / pharmacology
Myocardium / metabolism*
Oxygen Consumption* / drug effects
Pulmonary Artery / physiology
Chemical
Reg. No./Substance:
390-28-3/Methoxamine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Atrioventricular nodal conduction during atrial fibrillation in rabbit heart.
Next Document:  Different forms of spontaneous discharge induced by strophanthidin in cardiac Purkinje fibers.