Document Detail

Right and left ventricular geometry and myocyte contractile processes with dilated cardiomyopathy: myocyte growth and beta-adrenergic responsiveness.
MedLine Citation:
PMID:  8730409     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Comparison of the effects of supraventricular tachycardia-induced dilated cardiomyopathy on left and right ventricular isolated myocyte geometry and function. BACKGROUND: Chronic ventricular tachycardia and supraventricular tachycardia cause left ventricular dilation and dysfunction in humans. However, it is unknown whether supraventricular tachycardia-induced dilated cardiomyopathy is a homogenous process for both the left and right ventricles. METHODS: Dilated cardiomyopathy was induced by rapid atrial pacing (240 beats/min, 3 weeks) in 5 pigs. Five age- and weight-matched pigs served as controls. Ventricular mass was measured, myocyte dimensions were obtained, and isolated right and left ventricular myocyte contractile performance was evaluated at baseline and after beta-adrenergic receptor stimulation. RESULTS: With the development of dilated cardiomyopathy, there was no change in left ventricular mass. In contrast, right ventricular mass was increased, as was right ventricular myocyte cross-sectional area. In the control group, baseline right ventricular myocyte contractile function was increased compared to left ventricular myocytes. beta-adrenergic receptor stimulation increased myocyte contractile function in both left and right ventricular myocytes. With supraventricular tachycardia-induced cardiomyopathy, both left and right ventricular myocyte contractile function and beta-adrenergic responsiveness were reduced. CONCLUSIONS: This study demonstrated differences in left and right ventricular myocyte growth with supraventricular tachycardia-induced dilated cardiomyopathy and this differential growth response was associated with changes in contractile performance. Thus, in this model of cardiomyopathic disease, left and right ventricular growth and changes in contractile performance are not a homogenous process.
W S McMahon; R Mukherjee; P C Gillette; F A Crawford; F G Spinale
Related Documents :
12234819 - Tlr4 inactivation and rbpi(21) block burn-induced myocardial contractile dysfunction.
1764219 - Effect of moniliformin on myocardial contractility in rats.
17255859 - Levosimendan improves right ventriculovascular coupling in a porcine model of right ven...
9127439 - Contractile responses to histamine, serotonin, and angiotensin ii are impaired by 17 be...
3173179 - Verapamil withdrawal as a possible cause of myocardial infarction in a hypertensive wom...
23210039 - The usefulness of compliant balloon for recanalization of acute ischemic stroke.
23469229 - The novel mas agonist, cgen-856s, attenuates isoproterenol-induced cardiac remodeling a...
22919979 - In-hospital outcomes of primary percutaneous coronary intervention in king chulalongkor...
8087259 - Acute coronary embolism complicating aortic valve endocarditis treated with streptokina...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular research     Volume:  31     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-02-05     Completed Date:  1997-02-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  314-23     Citation Subset:  IM    
Division of Pediatric Cardiology, Medical University of South Carolina, Charleston 29425, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic beta-Agonists / pharmacology*
Cardiomyopathy, Dilated / pathology*
Cell Size / drug effects
Cells, Cultured
Heart Ventricles / pathology
Isoproterenol / pharmacology*
Myocardium / pathology*
Random Allocation
Stimulation, Chemical
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Agonists; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Specific mitochondrial DNA deletions in idiopathic dilated cardiomyopathy.
Next Document:  Doxazosin blocks the angiotensin II-induced smooth muscle cell DNA synthesis in the media, but not i...