Document Detail


Right and left isovolumic ventricular relaxation time intervals compared in patients by means of a single-pulsed Doppler method.
MedLine Citation:
PMID:  9339419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Right and left isovolumic ventricular relaxation time intervals measurements were obtained as follows: from the peak R wave on the electrocardiogram to either the mitral or the tricuspid pulsed Doppler flow trace onset minus the R to end-ejection zero flow crossing of the subaortic (left side) or pulmonary (right side) D flow trace time interval. A ratio was calculated as a percent difference duration between both isovolumic ventricular relaxation time intervals. The aim was to compare isovolumic ventricular relaxation time interval values in 42 healthy controls and to study the changes induced by heart diseases in 27 patients with (1) controlled hypertension without left ventricular hypertrophy, (2) hypertrophic cardiomyopathy, and (3) Cor pulmonale. Mean values of isovolumic ventricular relaxation time intervals significantly differed at paired and unpaired studies, with right isovolumic ventricular relaxation time intervals shorter than those of the left side in all groups (p < 0.001) except for patients with Cor pulmonale. Isovolumic ventricular relaxation time intervals did not correlate with heart rate and moderately correlated with left ventricular mass and age. No significant difference was found between healthy controls and patients with controlled hypertension. Significant changes were found in patients with hypertrophic cardiomyopathy and Cor pulmonale versus healthy controls for both isovolumic ventricular relaxation time intervals. However, significant changes in the ratio were only found in patients with Cor pulmonale (p < 0.005) because of abnormal similar values for both isovolumic ventricular relaxation time intervals. This Doppler method enabled, for the first time, serial comparison of isovolumic ventricular relaxation time intervals with a homologous method. Both isovolumic ventricular relaxation time intervals significantly lengthened with age and with left ventricular indexed mass, but their ratio remained insignificantly changed except for patients with Cor pulmonale. The concomitant right and left isovolumic ventricular relaxation time intervals lengthening in patients with hypertrophic cardiomyopathy and Cor pulmonale suggests interdependence of both ventricles through the septum. This makes recommendable systematic comparison of both sides. The calculation of a ratio, free from the effect of factors intervening on isovolumic ventricular relaxation time intervals, may, in addition, be of diagnostic help.
Authors:
F Larrazet; D Pellerin; C Fournier; S Witchitz; C Veyrat
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  10     ISSN:  0894-7317     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-12-02     Completed Date:  1997-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  699-706     Citation Subset:  IM    
Affiliation:
University Hospital Bicêtre, Department of Cardiology, France.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Aortic Valve / physiology,  ultrasonography
Blood Flow Velocity / physiology
Cardiac Output / physiology
Cardiac Volume / physiology*
Cardiomyopathy, Hypertrophic / physiopathology,  ultrasonography
Diastole / physiology*
Echocardiography, Doppler, Pulsed*
Electrocardiography
Female
Heart Rate / physiology
Heart Septum / physiopathology,  ultrasonography
Heart Ventricles / ultrasonography
Humans
Hypertension / physiopathology,  prevention & control,  ultrasonography
Male
Middle Aged
Mitral Valve / physiology,  ultrasonography
Prospective Studies
Pulmonary Heart Disease / physiopathology,  ultrasonography
Pulmonary Valve / physiology,  ultrasonography
Stroke Volume / physiology
Time Factors
Tricuspid Valve / physiology,  ultrasonography
Ventricular Function, Left / physiology*
Ventricular Function, Right / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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