Document Detail


Right hemisphere language mapping in patients with bilateral language.
MedLine Citation:
PMID:  15907753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The configuration of language cortex in the dominant left hemisphere has been well described in the literature. However, language representation in the right hemisphere, particularly in patients with some degree of bilateral language, remains unclear. Herein, we report six patients who underwent electrocortical stimulation (ECS) for language mapping following implantation of a right subdural electrode array (SEA). METHODS: The medical records of six bilateral language patients with right SEA implantation at the Minnesota Epilepsy Group between January 1996 and July 2004 were retrospectively reviewed. Language lateralization was based on the results of the intracarotid amobarbital procedure performed preoperatively. Anatomical localization of the SEA for each patient was verified using colored photographs of the cortical surface before and after SEA placement and by review of MRI scans taken with the SEA in place. Frontal and temporal language areas were identified by errors in any language modality including automatic speech, reading, naming, repetition, and comprehension during ECS. RESULTS: Language maps revealed the presence of frontal and/or temporal language areas analogous to the classic essential language areas of the dominant left hemisphere in four of six patients. One patient had a widespread distribution of single-language-error sites over the right temporal lobe. One patient had a silent language map. CONCLUSION: Our results identified the presence of language cortex in the right hemisphere in five of six patients classified with bilateral language based on intracarotid amobarbital procedure. These areas are assumed to be accessory language zones in relation to the left hemisphere. Further exploratory studies are needed to evaluate their clinical significance.
Authors:
Rosette A Jabbour; Ann Hempel; John R Gates; Wenbo Zhang; Gail L Risse
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  6     ISSN:  1525-5050     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-23     Completed Date:  2005-07-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  587-92     Citation Subset:  IM    
Affiliation:
Minnesota Epilepsy Group, PA, St. Paul, MN, USA. drrjabbour@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amobarbital / administration & dosage,  diagnostic use
Brain Mapping*
Child
Dominance, Cerebral / physiology*
Electric Stimulation / methods*
Epilepsy / diagnosis,  physiopathology*,  surgery
Female
Humans
Injections, Intra-Arterial
Language*
Language Tests / statistics & numerical data
Magnetic Resonance Imaging / methods
Male
Psychosurgery / methods
Retrospective Studies
Temporal Lobe / pathology,  physiopathology*,  surgery
Chemical
Reg. No./Substance:
57-43-2/Amobarbital

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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