Document Detail

Right heart dysfunction in post-tuberculosis emphysema.
MedLine Citation:
PMID:  15455598     Owner:  NLM     Status:  MEDLINE    
SETTING: University-affiliated general hospital. OBJECTIVE: To evaluate the pump performance of right heart before and after exercise in post-tuberculosis emphysema. DESIGN: In patients with post-tuberculosis or primary emphysema (similar lung volumes), body plethysmography, arterial blood gas analysis and echocardiography were performed at rest and after exercise. Right heart pump performance was evaluated with the ejection fraction. RESULTS: At rest, in post-tuberculosis emphysema, diffusing capacity (mean +/- SE 72.7 +/- 3.9 vs. 91.0 +/- 7.1% of reference) and right ventricular ejection fraction (57.5 + 1.4 vs. 61.3 +/- 1.2%) were lower and PaCO2 (42.7 +/- 1.1 vs. 38.6 +/- 0.7 mmHg) was higher, while lung compliance, airway resistance, PaO2, and alveolar-arterial oxygen difference were not different. After exercise, PaO2 (65.6 +/- 2.8 vs. 80.5 +/- 3.5 mmHg) and right ventricular ejection fraction (51.2 +/- 2.4 vs. 59.6 +/- 1.7%) were lower and PaCO2 (47.0 +/- 1.5 vs. 40.9 +/- 1.5 mmHg) was higher in post-tuberculosis emphysema, whereas alveolar-arterial oxygen difference was not different. PaCO2 and alveolar-arterial oxygen difference increased, and PaO2 and right ventricular ejection fraction decreased in post-tuberculosis emphysema, while they did not significantly change in primary emphysema. CONCLUSION: In post-tuberculosis emphysema, the impairment of gas exchange was more serious. Global assessment should be focused on right heart dysfunction which might be more affected than in primary emphysema.
M A Kim; S H Kim; J H Zo; B Hwangbo; J H Lee; H S Chung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  8     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-30     Completed Date:  2004-11-26     Revised Date:  2006-06-12    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  1120-6     Citation Subset:  IM    
Seoul National University Boramae Hospital, Seoul, Republic of Korea.
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MeSH Terms
Blood Gas Analysis
Carbon Dioxide / blood
Emphysema / complications*,  etiology*
Hospitals, University / statistics & numerical data
Middle Aged
Oxygen / blood
Respiratory Function Tests
Tuberculosis, Pulmonary / complications*
Ventricular Dysfunction, Right / etiology*,  pathology,  ultrasonography
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

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