| Right atrial predominance of atrial natriuretic peptide secretion in isolated perfused rat atria. | |
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MedLine Citation:
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PMID: 1533723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to investigate the regulatory mechanism for the atrial release of atrial natriuretic peptide (ANP), a perfused rabbit atrial model was devised. In the present experiments, the effect of a reduction in atrial distension on the immunoreactive ANP (irANP) secretion was investigated and compared in the perfused right and left atria of rats. Elevations in right and left atrial pressure resulted in proportional increases in the volume of atrial distension-reduction which was larger in the right than in the left atria. The basal rate of irANP secretion was higher in the right than in the left atria. Increases in the volume of atrial distension-reduction resulted in proportional increases in irANP secretion in both atria. Increment in irANP secretion in response to a reduction in atrial distension was significantly higher in the right than in the left atria. Higher rate of irANP secretion in response to unit volume change was observed in the right atria. Increases in the volume of atrial distension-reduction resulted in accentuated irANP responses in the right atrium. IrANP content was significantly higher in the right than in the left atria. The results suggest that the right atrium is a predominant site in ANP secretion in rats. |
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Authors:
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K H Seul; K W Cho; S H Kim |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Regulatory peptides Volume: 39 ISSN: 0167-0115 ISO Abbreviation: Regul. Pept. Publication Date: 1992 Apr |
Date Detail:
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Created Date: 1992-06-10 Completed Date: 1992-06-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 67-81 Citation Subset: IM |
Affiliation:
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Department of Physiology, Jeonbug National University, Medical School, Jeonju, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Function, Right / physiology Atrial Natriuretic Factor / analysis, secretion* Chromatography, High Pressure Liquid Heart Atria / secretion* Male Perfusion Radioimmunoassay Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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