Document Detail


Right ventricular structure is associated with the risk of heart failure and cardiovascular death: the Multi-Ethnic Study of Atherosclerosis (MESA)--right ventricle study.
MedLine Citation:
PMID:  22932258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline.
METHODS AND RESULTS: The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging on 5098 participants between 2000 and 2002 with follow-up for incident heart failure and cardiovascular death ("death") until January 2008. RV volumes and mass were available for 4204 participants. The study sample (n=4144) was 61.4±10.1 years old and 47.6% male. The presence of RV hypertrophy (increased RV mass) was associated with more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (hazard ratio, 2.52; 95% confidence interval, 1.55-4.10; P<0.001) and a doubling (or more) of risk with left ventricular mass at the mean value or lower (P for interaction=0.05).
CONCLUSIONS: RV hypertrophy was associated with the risk of heart failure or death in a multiethnic population free of clinical cardiovascular disease at baseline.
Authors:
Steven M Kawut; R Graham Barr; João A C Lima; Amy Praestgaard; W Craig Johnson; Harjit Chahal; Kofo O Ogunyankin; Michael R Bristow; Jorge R Kizer; Harikrishna Tandri; David A Bluemke
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2012-08-29
Journal Detail:
Title:  Circulation     Volume:  126     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2012-12-11     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1681-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cohort Studies
Coronary Artery Disease / ethnology*,  mortality,  pathology*
Death*
Ethnic Groups / ethnology
Female
Follow-Up Studies
Heart Failure / ethnology*,  mortality,  pathology*
Heart Ventricles / pathology*
Humans
Male
Middle Aged
Prospective Studies
Grant Support
ID/Acronym/Agency:
K24 HL103844/HL/NHLBI NIH HHS; K24-HL103844/HL/NHLBI NIH HHS; N01-HC95159/HC/NHLBI NIH HHS; N01-HC95169/HC/NHLBI NIH HHS; R01 HL077612/HL/NHLBI NIH HHS; R01 HL086719/HL/NHLBI NIH HHS; R01 HL093081/HL/NHLBI NIH HHS; R01-HL077612/HL/NHLBI NIH HHS; R01-HL086719/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Circulation. 2012 Oct 2;126(14):1673-5   [PMID:  22932259 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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