| Right ventricular oscillatory power is a constant fraction of total power irrespective of pulmonary artery pressure. | |
| | |
MedLine Citation:
|
PMID: 20622041 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
RATIONALE: Pulmonary hypertension (PH) is characterized by increased arterial load requiring more right ventricular (RV) hydraulic power to sustain adequate forward blood flow. Power can be separated into a mean and oscillatory part. The former is associated with mean and the latter with pulsatile blood flow and pressure. Because mean power provides for net blood flow, the ratio of oscillatory to total power (oscillatory power fraction) preferably should be small. It is unknown whether this is the case in pulmonary arterial hypertension (PAH). OBJECTIVES: To derive components of power generated by the right ventricle in PAH. MEASUREMENTS AND MAIN RESULTS: Thirty-five patients with idiopathic PAH (IPAH) and 14 subjects without PH were included. The patients were divided in two groups, "moderate" and "high," based on pulmonary artery (PA) pressure. PA pressures were obtained by right heart catheterization and PA flows by magnetic resonance imaging. Total hydraulic power (Power(total)) was calculated as the integral product of pressure and flow. Mean hydraulic power (Power(mean)) was calculated as mean pulmonary artery pressure times mean flow. Their difference is oscillatory power (Power(oscill)). Total hydraulic power in subjects without PH compared with moderate and high IPAH was 0.29 ± 0.10 W (n = 14), 0.52 ± 0.14 W (n = 17), and 0.73 ± 0.24 W (n = 18), respectively. The oscillatory power fraction is approximately 23% and not different between groups. CONCLUSIONS: In this study, oscillatory power fraction is constant at 23% in non-PH and IPAH, implying that a considerable amount of power is not used for forward flow, making the RV less efficient with respect to its arterial load. Our findings emphasize the need to develop new therapy strategies to optimize RV power output in PAH. |
| | |
Authors:
|
Nabil Saouti; Nico Westerhof; Frank Helderman; J Tim Marcus; Anco Boonstra; Pieter E Postmus; Anton Vonk-Noordegraaf |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-09 |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 182 ISSN: 1535-4970 ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-16 Completed Date: 2010-12-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 1315-20 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pulmonary Diseases, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Flow Velocity / physiology Blood Pressure / physiology Case-Control Studies Female Heart Ventricles / physiopathology Humans Hypertension, Pulmonary / physiopathology Magnetic Resonance Imaging Male Middle Aged Pulmonary Artery / physiology, physiopathology Pulmonary Wedge Pressure / physiology* Ventricular Function, Right / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal ...
Next Document: Apelin attenuates hyperoxic lung and heart injury in neonatal rats.