Document Detail


Right ventricular inefficiency in repaired tetralogy of Fallot: proof of concept for energy calculations from cardiac MRI data.
MedLine Citation:
PMID:  20589531     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Repaired tetralogy of Fallot (rTOF) patients develop right ventricular (RV) dilatation and dysfunction. To prevent their demise, pulmonary valve replacement is necessary, though appropriate timing for it is challenged by a paucity of reliable diagnostic parameters. In this pilot study, we hypothesized that stroke work (SW) and energy calculations would delineate the inefficiency of RV performance in rTOF. RV SW was calculated for both an rTOF and a normal subject by utilizing RV pressure and volume measurements obtained during cardiac catheterization and MRI studies. Energy transfer rate and ratio were computed at the main pulmonary artery (PA). Compared to the normal RV, the rTOF RV had higher operating pressure, lower computed SW (0.078 J vs. 0.115 J for normal), and higher negative energy transfer at the PA (0.044 J vs. 0.002 J for normal). Furthermore, the energy transfer ratio was nearly twice as high for the normal RV (1.06) as for the rTOF RV (0.56). RV SW and energy transfer ratio delineate important operational efficiency differences in blood flow from the RV to the PA between rTOF and normal subjects. Our pilot data suggest that the rTOF RV is significantly less efficient than normal.
Authors:
Ashish Das; Rupak K Banerjee; William M Gottliebson
Publication Detail:
Type:  Journal Article     Date:  2010-06-30
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-03-01     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3674-87     Citation Subset:  IM    
Affiliation:
Department of Mechanical Engineering, University of Cincinnati, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Biomedical Engineering
Child, Preschool
Coronary Circulation
Female
Heart Valve Prosthesis Implantation
Heart Ventricles / physiopathology
Humans
Hydrodynamics
Magnetic Resonance Angiography
Male
Pilot Projects
Pulmonary Valve / physiopathology,  surgery
Retrospective Studies
Stroke Volume / physiology
Tetralogy of Fallot / physiopathology*,  surgery
Ventricular Dysfunction, Right / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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