| Right ventricular failure: a novel era of targeted therapy. | |
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MedLine Citation:
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PMID: 20890792 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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There now is strong evidence to recognize the pivotal role of the right ventricle (RV) in heart disease and to establish it as a unique and separate entity than the left ventricle (LV). Here, we summarize the differences between the two ventricles, the diagnosis of RV failure, and the management of acute and chronic RV failure. We review the indices derived by echocardiography used to measure RV function, and novel biomarkers that may play a role diagnosing and prognosticating in RV-specific disease. There are new novel therapies that specifically target the RV in disease. For example, phosphodiesterase type 5 inhibitors improve contractility of the hypertrophied RV while sparing the normal LV in pulmonary arterial hypertension. The metabolism of the hypertrophied RV is another area for therapeutic exploitation by metabolic modulation. We also suggest future potential molecular targets that may be unique to the RV because they are upregulated in RV hypertrophy greater than in LV hypertrophy. |
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Authors:
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Dipanjan Banerjee; Francois Haddad; Roham T Zamanian; Jayan Nagendran |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current heart failure reports Volume: 7 ISSN: 1546-9549 ISO Abbreviation: Curr Heart Fail Rep Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101196487 Medline TA: Curr Heart Fail Rep Country: United States |
Other Details:
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Languages: eng Pagination: 202-11 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk Cardiovascular Research Building, 300 Pasteur Drive, Stanford, CA 94305, USA. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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