Document Detail


Right ventricular failure: a novel era of targeted therapy.
MedLine Citation:
PMID:  20890792     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
There now is strong evidence to recognize the pivotal role of the right ventricle (RV) in heart disease and to establish it as a unique and separate entity than the left ventricle (LV). Here, we summarize the differences between the two ventricles, the diagnosis of RV failure, and the management of acute and chronic RV failure. We review the indices derived by echocardiography used to measure RV function, and novel biomarkers that may play a role diagnosing and prognosticating in RV-specific disease. There are new novel therapies that specifically target the RV in disease. For example, phosphodiesterase type 5 inhibitors improve contractility of the hypertrophied RV while sparing the normal LV in pulmonary arterial hypertension. The metabolism of the hypertrophied RV is another area for therapeutic exploitation by metabolic modulation. We also suggest future potential molecular targets that may be unique to the RV because they are upregulated in RV hypertrophy greater than in LV hypertrophy.
Authors:
Dipanjan Banerjee; Francois Haddad; Roham T Zamanian; Jayan Nagendran
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current heart failure reports     Volume:  7     ISSN:  1546-9549     ISO Abbreviation:  Curr Heart Fail Rep     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101196487     Medline TA:  Curr Heart Fail Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  202-11     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk Cardiovascular Research Building, 300 Pasteur Drive, Stanford, CA 94305, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Opiate sparing effect of fixed combination of diclophenac and orphenadrine after unilateral total hi...
Next Document:  Selective KIT inhibitor KI-328 and HSP90 inhibitor show different potency against the type of KIT mu...