Document Detail

Right and left ventricular diastolic pressure-volume relations: a comprehensive review.
MedLine Citation:
PMID:  23179133     Owner:  NLM     Status:  MEDLINE    
Ventricular compliance alterations can affect cardiac performance and adaptations. Moreover, diastolic mechanics are important in assessing both diastolic and systolic function, since any filling impairment can compromise systolic function. A sigmoidal passive filling pressure-volume relationship, developed using chronically instrumented, awake-animal disease models, is clinically adaptable to evaluating diastolic dynamics using subject-specific micromanometric and volumetric data from the entire filling period of any heartbeat(s). This innovative relationship is the global, integrated expression of chamber geometry, wall thickness, and passive myocardial wall properties. Chamber and myocardial compliance curves of both ventricles can be computed by the sigmoidal methodology over the entire filling period and plotted over appropriate filling pressure ranges. Important characteristics of the compliance curves can be examined and compared between the right and the left ventricle and for different physiological and pathological conditions. The sigmoidal paradigm is more accurate and, therefore, a better alternative to the conventional exponential pressure-volume approximation.
Ares Pasipoularides
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-11-21
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  6     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-23     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-52     Citation Subset:  IM    
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MeSH Terms
Biomechanical Phenomena
Heart Rate
Models, Cardiovascular
Stroke Volume*
Ventricular Function, Left*
Ventricular Function, Right*
Ventricular Pressure*
Grant Support
R01 HL050446/HL/NHLBI NIH HHS; R01 NIH 50446//PHS HHS

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