Document Detail


Rifaximin for the prevention of spontaneous bacterial peritonitis.
MedLine Citation:
PMID:  22529702     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
According to a review article by Biecker et al published in a previous issue of World Journal of Gastroenterology in March 2011, intestinal decontamination with norfloxacin remains the mainstay of primary prophylaxis of spontaneous bacterial peritonitis (SBP) at the expense of development of quinolone-resistant bacteria after long-term use. In our research, the administration of a 4-wk regimen with rifaximin 1200 mg/d reduced significantly the ascitic neutrophil count in cirrhotic patients with sterile ascites in line with a significant decrease in plasma endotoxin levels. Our observations concur with recent findings, showing a significantly reduced 5-year probability of SBP in cirrhotic patients taking rifaximin.
Authors:
Georgios N Kalambokis; Athanasia Mouzaki; Maria Rodi; Epameinondas V Tsianos
Publication Detail:
Type:  Comment; Letter    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  18     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-10-11     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1700-2     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Ascites / diagnosis*,  therapy*
Humans
Liver Cirrhosis / diagnosis*,  therapy*
Comments/Corrections
Comment On:
World J Gastroenterol. 2011 Mar 14;17(10):1237-48   [PMID:  21455322 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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