Document Detail

Rifaximin in the treatment of irritable bowel syndrome: is there a high risk for development of antimicrobial resistance?
MedLine Citation:
PMID:  23340064     Owner:  NLM     Status:  MEDLINE    
Irritable bowel syndrome (IBS), a chronic, nonfatal illness is commonly encountered in clinical practice; however, treatment options are limited and often ineffectual. Despite this, there is increasing evidence that bacterial overgrowth in the bowel (dysbiosis) may be an etiological factor in IBS. This has lead to studies in which the antibiotic agent rifaximin has been used to reduce the microbial burden in the bowel, to some extent alleviating the symptoms of IBS. Rifaximin is a member of the rifamycin class of antibiotics, which when administered orally has the distinctions of being gut specific coupled with poor systemic absorption, characteristics that are suggested to limit the development of bacterial resistance. The rifamycins are currently used to treat serious human diseases including tuberculosis, meningococcal disease, methicillin-resistant Staphylococcus aureus and Clostridium difficile infections. The use of rifamycins in the treatment of these diseases is associated with the development of antibiotic resistance over time. When considering the importance of the rifamycins in the treatment of serious human diseases, the large number of patients affected by IBS, and the lack of scientific evidence available on the development of antibiotic resistance to rifaximin over the long-term when used in the gut, it is advisable that the use of rifaximin as a therapy for IBS should be limited to single, acute, short-term treatment.
David J Farrell
Related Documents :
24624034 - Prophylaxis with levofloxacin: impact on bacterial susceptibility and epidemiology in a...
20177904 - New method for quantification of trypanosoma cruzi in animal's tissue in the chronic ph...
23857384 - Risk factors for bacteremia due to extended-spectrum beta-lactamase-producing escherich...
16729674 - Effects of polyamines on two strains of trypanosoma brucei in infected rats and in vitr...
19344 - Characterization of salmonella typhimurium mutants with altered glutamine synthetase ac...
10758864 - Revision of species delineation in the genus ectothiorhodospira.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  47     ISSN:  1539-2031     ISO Abbreviation:  J. Clin. Gastroenterol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-07-29     Revised Date:  2013-10-23    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
JMI Laboratories, North Liberty, IA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Infective Agents / administration & dosage,  pharmacology*
Drug Resistance, Bacterial
Gastrointestinal Agents / administration & dosage,  pharmacology
Irritable Bowel Syndrome / drug therapy*,  microbiology
Rifamycins / administration & dosage,  pharmacology*
Time Factors
Reg. No./Substance:
0/Anti-Infective Agents; 0/Gastrointestinal Agents; 0/Rifamycins; 88747-56-2/rifaximin
Comment In:
J Clin Gastroenterol. 2013 Oct;47(9):814   [PMID:  23751850 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interobserver Agreement for Confocal Imaging of Ampullary Lesions: A Multicenter Single-blinded Stud...
Next Document:  Survival of Hepatocellular Carcinoma Patients May be Improved in Surveillance Interval not More Than...