Document Detail


Rifampicin-induced Acute Kidney Injury During the Initial Treatment for Pulmonary Tuberculosis: A Case Report and Literature Review.
MedLine Citation:
PMID:  24190152     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A 47-year-old man diagnosed with pulmonary tuberculosis was referred to our hospital. Rifampicin, isoniazid, pyrazinamide and ethambutol were administered, and the patient's symptoms promptly improved. On the 19th hospital day, he developed acute kidney injury with a fever and chills. Renal biopsy specimens indicated tubulointerstitial nephritis. Suspecting rifampicin-induced acute kidney injury, we discontinued the rifampicin and administered levofloxacin in its place. The patient's serum creatinine level subsequently gradually improved. We herein report this case and review eight cases reported in Japan. We found that the rifampicin toxicity appeared at both the initial administration and readministration. All eight patients presented with proteinuria.
Authors:
Sahoko Chiba; Kimitake Tsuchiya; Hiroyuki Sakashita; Eisaku Ito; Naohiko Inase
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  52     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2013  
Date Detail:
Created Date:  2013-11-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2457-60     Citation Subset:  IM    
Affiliation:
Department of Respiratory Medicine, Tokyo Medical and Dental University, Japan.
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