Document Detail

Riedel's thyroiditis containing cytologically atypically appearing B-cells: a case report.
MedLine Citation:
PMID:  14521268     Owner:  NLM     Status:  MEDLINE    
We report on a case of Riedel's thyroiditis containing cytologically atypically appearing B-cells. The patient was a 60-year-old Japanese female, who had a well-demarcated tumor that showed extensive growth from the right thyroid lobe into perithyroidal soft tissues. Histologically, the lesion consisted of two components. The central tumor-like portion of the mass showed spindle cells intermixed with abundant collagen fibers. In addition, scattered B-cells with large nuclei and multiple small, but conspicuous nucleoli were also present. At the periphery of the nodule, numerous plasma cells and small lymphocytes, as well as occasional B-immunoblasts and plasmablasts were growing between non-neoplastic thyroid follicles. An infiltration of thyroid follicles by B-cells also resulted in lymphoepithelial-like lesions. The specimen obtained from an enlarged cervical lymph node occurring 14 months later contained numerous mature plasma cells showing a sheet-like arrangement with occasional immature plasma cells and immunoblasts in the interfollicular area and medullary cords. The polyclonal nature of B-cells was demonstrated immunohistochemically and by polymerase chain reaction in both the thyroid gland and the lymph node lesion.
Masaru Kojima; Shigeo Nakamura; Yuko Yamane; Ken Shimizu; Shiro Sugiharal; Nobuhide Masawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pathology, research and practice     Volume:  199     ISSN:  0344-0338     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-02     Completed Date:  2004-04-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  497-501     Citation Subset:  IM    
Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan.
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MeSH Terms
B-Lymphocytes / metabolism,  pathology*
Carcinoma / diagnosis
DNA, Neoplasm / analysis
Diagnosis, Differential
Immunoenzyme Techniques
In Situ Hybridization
Lymphoma, B-Cell / complications,  metabolism,  pathology*
Lymphoma, Large B-Cell, Diffuse / complications,  metabolism,  pathology*
Middle Aged
Polymerase Chain Reaction
Thyroid Gland / metabolism,  pathology*,  surgery
Thyroid Neoplasms / diagnosis
Thyroiditis, Autoimmune / complications,  metabolism,  pathology*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/DNA, Neoplasm; 0/Tumor Markers, Biological

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