| Riedel's thyroiditis containing cytologically atypically appearing B-cells: a case report. | |
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MedLine Citation:
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PMID: 14521268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report on a case of Riedel's thyroiditis containing cytologically atypically appearing B-cells. The patient was a 60-year-old Japanese female, who had a well-demarcated tumor that showed extensive growth from the right thyroid lobe into perithyroidal soft tissues. Histologically, the lesion consisted of two components. The central tumor-like portion of the mass showed spindle cells intermixed with abundant collagen fibers. In addition, scattered B-cells with large nuclei and multiple small, but conspicuous nucleoli were also present. At the periphery of the nodule, numerous plasma cells and small lymphocytes, as well as occasional B-immunoblasts and plasmablasts were growing between non-neoplastic thyroid follicles. An infiltration of thyroid follicles by B-cells also resulted in lymphoepithelial-like lesions. The specimen obtained from an enlarged cervical lymph node occurring 14 months later contained numerous mature plasma cells showing a sheet-like arrangement with occasional immature plasma cells and immunoblasts in the interfollicular area and medullary cords. The polyclonal nature of B-cells was demonstrated immunohistochemically and by polymerase chain reaction in both the thyroid gland and the lymph node lesion. |
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Authors:
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Masaru Kojima; Shigeo Nakamura; Yuko Yamane; Ken Shimizu; Shiro Sugiharal; Nobuhide Masawa |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pathology, research and practice Volume: 199 ISSN: 0344-0338 ISO Abbreviation: Pathol. Res. Pract. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-10-02 Completed Date: 2004-04-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7806109 Medline TA: Pathol Res Pract Country: Germany |
Other Details:
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Languages: eng Pagination: 497-501 Citation Subset: IM |
Affiliation:
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Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan. mkojima@gunma-cc.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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B-Lymphocytes
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metabolism,
pathology* Carcinoma / diagnosis DNA, Neoplasm / analysis Diagnosis, Differential Female Humans Immunoenzyme Techniques In Situ Hybridization Lymphoma, B-Cell / complications, metabolism, pathology* Lymphoma, Large B-Cell, Diffuse / complications, metabolism, pathology* Middle Aged Polymerase Chain Reaction Thyroid Gland / metabolism, pathology*, surgery Thyroid Neoplasms / diagnosis Thyroiditis, Autoimmune / complications, metabolism, pathology* Tumor Markers, Biological / analysis |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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