Document Detail

Rickets in very low birthweight infants. Influence of supplementation with vitamin D, phosphorus and calcium.
MedLine Citation:
PMID:  3564975     Owner:  NLM     Status:  MEDLINE    
The influence of extra phosphorus (P) and calcium (Ca) on the incidence of rickets was studied in 40 infants with a birthweight below 1.5 kg. All were fed breastmilk and all received vitamin D 1200 IU/day. Half of the infants were supplemented with P 20 mg/kg/day and Ca 30 mg/kg/day. Rickets, diagnosed with X-ray at 5 to 7 weeks of age, developed in 12 infants, 11 of whom weighed below 1.0 kg. In infants below 1.0 kg rickets was significantly more common in the group not receiving extra P and Ca. After diagnosis all were substituted and radiographic healing occurred in all. Serum Ca concentrations were normal in both groups whereas serum P was significantly lower in non-supplemented patients. Serum alkaline phosphatases (ALP) were normal in all patients at the time of diagnosis demonstrating the risk of using ALP as a diagnostic test for rickets in very low birthweight.
M Lindroth; U Westgren; S Laurin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  75     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-05-21     Completed Date:  1987-05-21     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  927-31     Citation Subset:  IM    
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MeSH Terms
Alkaline Phosphatase / blood
Calcium / administration & dosage*,  blood
Infant, Low Birth Weight*
Infant, Newborn
Phosphorus / administration & dosage*,  blood
Rickets / diagnosis,  etiology,  prevention & control*
Vitamin D / administration & dosage*
Reg. No./Substance:
1406-16-2/Vitamin D; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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