Document Detail

Rickets in Nigerian children: response to calcium supplementation.
MedLine Citation:
PMID:  10467830     Owner:  NLM     Status:  MEDLINE    
In a previous study of rachitic children in Jos, Nigeria we concluded that inadequate dietary intake of calcium was the primary contributing factor to the development of their rickets. The objective of the present study was to determine the effect of calcium supplementation in 10 children with radiographically and biochemically proven rickets from the same geographical area. Rachitic children were provided with calcium supplements of 1000 mg/day for a period of 3 months. Serum and urine samples were obtained at baseline and at 24 hours, 1 week, 4 weeks, and 12 weeks after initiation of supplementation. Serum calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D were measured at each time point. Dietary recalls obtained at two separate times were used to estimate usual daily intakes of calcium and phosphorus. Ten non-rachitic age-matched controls from the same geographical area were recruited for comparison. Nine of 10 rachitic subjects had radiographic evidence of healing after 3 months of calcium therapy. Although serum calcium concentrations returned to control levels, other biochemical data indicated that the rickets of these subjects may have been multifactorial in aetiology, pointing to a possible defect in the synthesis of 25-hydroxyvitamin D.
T Thacher; R H Glew; C Isichei; J O Lawson; J K Scariano; B W Hollis; D J VanderJagt
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of tropical pediatrics     Volume:  45     ISSN:  0142-6338     ISO Abbreviation:  J. Trop. Pediatr.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8010948     Medline TA:  J Trop Pediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  202-7     Citation Subset:  IM    
Department of General Medical Practice, Jos University Teaching Hospital, Nigeria.
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MeSH Terms
Calcium, Dietary / metabolism,  therapeutic use*
Child, Preschool
Rickets / diet therapy*,  metabolism,  radiography
Statistics, Nonparametric
Reg. No./Substance:
0/Calcium, Dietary
Erratum In:
J Trop Pediatr 2000 Feb;46(1):62

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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