Document Detail

Ricin toxin hits a retrograde roadblock.
MedLine Citation:
PMID:  20403318     Owner:  NLM     Status:  PubMed-not-MEDLINE    
To inhibit protein synthesis and induce cell death, plant ricin toxin and bacterial Shiga toxins enter the cell through the endocytic and retrograde secretory pathways. Stechmann et al. (2010) now identify two small-molecule inhibitors that selectively block endosome-to-Golgi retrieval of ricin and Shiga toxins and protect mice from ricin's deadly effects.
Matthew N J Seaman; Andrew A Peden
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cell     Volume:  141     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-05-04     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-4     Citation Subset:  -    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Grant Support
G0700750//Medical Research Council; G120/952//Medical Research Council
Comment On:
Cell. 2010 Apr 16;141(2):231-42   [PMID:  20403321 ]

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