| Rice dwarf virus is engulfed into and released via vesicular compartments in cultured insect vector cells. | |
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MedLine Citation:
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PMID: 18931091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vector insect cells infected with Rice dwarf virus had vesicular compartments containing viral particles located adjacent to the viroplasm when examined by transmission electron and confocal microscopy. Such compartments were often at the periphery of infected cells. Inhibitors of vesicular transport, brefeldin A and monensin, and an inhibitor of myosin motor activity, butanedione monoxime, abolished the formation of such vesicles and prevented the release of viral particles from infected cells without significant effects on virus multiplication. Furthermore, the actin-depolymerizing drug, cytochalasin D, inhibited the formation of actin filaments without significantly interfering with formation of vesicular compartments and the release of viruses from treated cells. These results together revealed intracellular vesicular compartments as a mode for viral transport in and release from insect vector cells infected with a plant-infecting reovirus. |
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Authors:
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Taiyun Wei; Hiroyuki Hibino; Toshihiro Omura |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of general virology Volume: 89 ISSN: 0022-1317 ISO Abbreviation: J. Gen. Virol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2009-01-12 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0077340 Medline TA: J Gen Virol Country: England |
Other Details:
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Languages: eng Pagination: 2915-20 Citation Subset: IM |
Affiliation:
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National Agricultural Research Center, 3-1-1 Kannondai, Tsukuba, Ibaraki 305-8666, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brefeldin A / pharmacology Insect Vectors Insects / virology Microscopy, Confocal Myosins / drug effects, physiology Oryza sativa / virology* Reoviridae / isolation & purification, physiology* Viral Proteins / drug effects, physiology Viruses |
| Chemical | |
Reg. No./Substance:
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0/Viral Proteins; 20350-15-6/Brefeldin A; EC 3.6.4.1/Myosins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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