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Ribozymes that can be regulated by external stimuli.
MedLine Citation:
PMID:  25146171     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Ribozymes have been known for about 30 years, and nowadays are understood well enough to be turned into useful tools for a number of applications in vitro and in vivo. Allosteric ribozymes switch on and off their activity in response to a specific chemical (ligand) or physical (temperature, light) signal. The possibility of controlling ribozyme activity by external stimuli is of particular relevance for applications in different fields, such as environmental and medicinal diagnostics, molecular computing, control of gene expression and others. Herein, we review recent advances and describe selected examples of addressable ribozymes.
Authors:
Jennifer Frommer; Bettina Appel; Sabine Müller
Publication Detail:
Type:  REVIEW     Date:  2014-8-18
Journal Detail:
Title:  Current opinion in biotechnology     Volume:  31C     ISSN:  1879-0429     ISO Abbreviation:  Curr. Opin. Biotechnol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9100492     Medline TA:  Curr Opin Biotechnol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  35-41     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ltd. All rights reserved.
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