| Ribosome-inactivating proteins: progress and problems. | |
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MedLine Citation:
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PMID: 16799768 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ribosome-inactivating proteins (RIPs), mostly from plants, are enzymes which depurinate rRNA, thus inhibiting protein synthesis. They also depurinate other polynucleotide substrates. The biological activity of RIPs is not completely clarified, and sometimes independent of the inhibition of protein synthesis. There are differences in the cytotoxicity of RIPs and, consequently, in their toxicity to animals. Some RIPs are potent toxins, the best known being ricin, a potential biological weapon. New toxins have recently been identified. RIPs cause apoptotic and necrotic lesions, and induce production of cytokines causing inflammation. RIPs are potentially useful in agriculture and medicine because (i) they have antiviral activity and (ii) they are used for the preparation of conjugates with antibodies ('immunotoxins') or other carriers, rendering them specifically toxic to the cell target of the carrier, which may be helpful in therapy. The distribution, mechanism of action and role in nature of RIPs are not completely understood, and we can expect several future developments in their practical application. |
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Authors:
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F Stirpe; M G Battelli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cellular and molecular life sciences : CMLS Volume: 63 ISSN: 1420-682X ISO Abbreviation: Cell. Mol. Life Sci. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-15 Completed Date: 2006-10-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9705402 Medline TA: Cell Mol Life Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1850-66 Citation Subset: IM |
Affiliation:
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Dipartimento di Patologia sperimentale, Alma Mater Studiorum Università di Bologna, Via S. Giacomo 14, 40126, Bologna, Italy. fiorenzo.stirpe@unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / therapeutic use Humans N-Glycosyl Hydrolases / metabolism*, therapeutic use, toxicity Neurons / drug effects Plant Proteins / metabolism*, therapeutic use, toxicity RNA, Plant / genetics RNA, Ribosomal / genetics RNA, Ribosomal, 28S / genetics Ribosomes / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Plant Proteins; 0/RNA, Plant; 0/RNA, Ribosomal; 0/RNA, Ribosomal, 28S; EC 3.2.2.-/N-Glycosyl Hydrolases |
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