| Ribonuclease S redux. | |
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MedLine Citation:
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PMID: 21079871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The S-peptide and S-protein components of bovine pancreatic ribonuclease form a noncovalent complex with restored ribonucleolytic activity. Although this archetypal protein-fragment complementation system has been the object of historic work in protein chemistry, intrinsic limitations compromise its utility. Modern methods are shown to overcome those limitations and enable new applications. |
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Authors:
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Rex W Watkins; Ulrich Arnold; Ronald T Raines |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-11-16 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: 47 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-24 Completed Date: 2011-04-11 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 973-5 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706-1544, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacillus subtilis / enzymology* Cattle Dexfenfluramine Models, Molecular Peptide Fragments / chemistry, metabolism Protein Conformation Ribonuclease, Pancreatic / chemistry*, metabolism* Subtilisin / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA073808/CA/NCI NIH HHS; R01 CA073808-14/CA/NCI NIH HHS; R01 GM044783/GM/NIGMS NIH HHS; R01 GM044783-20/GM/NIGMS NIH HHS; T32 GM008505/GM/NIGMS NIH HHS; T32 GM008505-18/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 3239-44-9/Dexfenfluramine; EC 3.1.27.5/Ribonuclease, Pancreatic; EC 3.4.21.62/Subtilisin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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