| Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up. | |
| | |
MedLine Citation:
|
PMID: 22277556 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: We recently reported that the elevated blood pressure (BP) observed in patients with cardiovascular disease who are homozygous for the 677C→T polymorphism (TT genotype) in the gene encoding methylenetetrahydrofolate reductase (MTHFR) was responsive to supplementation with riboflavin-the cofactor for MTHFR.Objective: The objective was to investigate the effect of riboflavin on BP targeted at patients with the TT genotype 4 y after initial investigation, during which time major changes in the clinical guidelines for antihypertensive therapy were introduced. DESIGN: A total of 83 patients (representing all 3 genotypes) who participated in a placebo-controlled riboflavin intervention for 16 wk in 2004 agreed to take part. Nested within this follow-up, those with the TT genotype (n = 31) proceeded to intervention with riboflavin (1.6 mg/d for 16 wk) or placebo, conducted in a crossover style whereby the 2004 treatment groups were reversed.Results: At follow-up in 2008, as in 2004, patients with the TT genotype had higher systolic BP (P < 0.01), with a nonsignificant trend noted for higher diastolic BP (P = 0.051). Despite the marked changes in antihypertensive therapy that had occurred, BP remained unchanged in patients with the TT genotype at the time of follow-up. Riboflavin supplementation (administered in 2004 and 2008) produced an overall decrease in systolic (-9.2 ± 12.8 mm Hg; P = 0.001) and diastolic (-6.0 ± 9.9 mm Hg; P = 0.003) BP. CONCLUSIONS: Optimizing riboflavin status offers a low-cost targeted strategy for managing elevated BP in this genetically at-risk group. These findings, if confirmed in the general population, could have important implications for the prevention of hypertension. |
| | |
Authors:
|
Carol P Wilson; Mary Ward; Helene McNulty; J J Strain; Tom G Trouton; Geraldine Horigan; John Purvis; John M Scott |
Related Documents
:
|
9349386 - Targeting of dobutamine to ischemic myocardium without systemic effects by selective su... 2514036 - Protection of the immature myocardium during ischemic arrest: dose dependent effects of... 7788906 - Heterogeneities in [k+]o and tq potential and the inducibility of ventricular fibrillat... 9689446 - Energy generation in hypertrophied postischemic myocardium. feasibility of prolonged in... 19056836 - Adeno-associated virus-mediated human c-reactive protein gene delivery causes endotheli... 14581126 - Sweet taste and blood pressure-related analgesia. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: - ISSN: 1938-3207 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inherited behavioral susceptibility to adiposity in infancy: a multivariate genetic analysis of appe...
Next Document: Insomnia, sleep quality, pain, and somatic symptoms: sex differences and shared genetic components.