Document Detail


Riboflavin in development and cell fate.
MedLine Citation:
PMID:  22116702     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Riboflavin (7,8-dimethyl-10-ribitylisoalloxazine; vitamin B2) is a water-soluble vitamin, cofactor derivatives of which (FAD, FMN) act as electron acceptors in the oxidative metabolism of carbohydrate, amino acids and fatty acids and which in the reduced state can donate electrons to complex II of the electron transport chain. This means that riboflavin is essential for energy generation in the aerobic cell, through oxidative phosphorylation. The classic effects of riboflavin deficiency on growth and development have generally been explained in terms of these functions. However, research also suggests that riboflavin may have specific functions associated with cell fate determination, which would have implications for growth and development. In particular, riboflavin depletion interferes with the normal progression of the cell cycle, probably through effects on the expression of regulatory genes, exerted at both the transcriptional and proteomic level.
Authors:
Hilary J Powers; B M Corfe; E Nakano
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Sub-cellular biochemistry     Volume:  56     ISSN:  0306-0225     ISO Abbreviation:  Subcell. Biochem.     Publication Date:  2012  
Date Detail:
Created Date:  2011-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0316571     Medline TA:  Subcell Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  229-45     Citation Subset:  IM    
Affiliation:
Human Nutrition Unit, The School of Medicine, The University of Sheffield, Sheffield, S10 2RX, UK, h.j.powers@sheff.ac.uk.
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