Document Detail

Rhythmicity, randomness and synchrony in climbing fiber signals.
MedLine Citation:
PMID:  16182386     Owner:  NLM     Status:  MEDLINE    
The role of the climbing fiber input to the cerebellum has been enigmatic, with recent studies focusing on its temporal and spatial firing patterns. Debate remains as to whether climbing fibers provide a periodic clock for coordinating movements or lead to long-term modification of Purkinje cell activity as the basis of motor learning. Rhythmic and synchronous activity of climbing fibers can cause movements at the same frequency in some preparations, suggesting a role in motor timing. However, in awake monkeys climbing fiber signals have been reported to occur at random, presenting a problem for clock theories. Yet synchronous patterns of discharge are consistently observed among several Purkinje cells within a narrow parasagittal longitudinal band. Here, we review recent experimental and theoretical studies and attempt to provide a coherent account of the interplay between rhythmicity, randomness and synchrony in climbing fiber activity, with a particular reference to studies in chaos.
Shigeru Kitazawa; Daniel M Wolpert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2005-09-22
Journal Detail:
Title:  Trends in neurosciences     Volume:  28     ISSN:  0166-2236     ISO Abbreviation:  Trends Neurosci.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-24     Completed Date:  2006-01-30     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  7808616     Medline TA:  Trends Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-9     Citation Subset:  IM    
Department of Physiology (I), Juntendo University School of Medicine, 2-1-1 Hongo, Tokyo 113-8421, Japan.
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MeSH Terms
Cerebellum / cytology,  physiology*
Cortical Synchronization*
Efferent Pathways / cytology,  physiology*
Mice, Knockout
Models, Neurological*
Nonlinear Dynamics
Purkinje Cells / physiology*
Grant Support
//Wellcome Trust
Comment In:
Trends Neurosci. 2006 Feb;29(2):65; author reply 66-7   [PMID:  16380170 ]

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