Document Detail


Rhythmic activity of feline dorsal and ventral spinocerebellar tract neurons during fictive motor actions.
MedLine Citation:
PMID:  23100134     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The dorsal spinocerebellar tracts (DSCT) have been described to be rhythmically active during walking on a treadmill in decerebrate cats, but this activity ceased following de-afferentation of the hindlimb. This observation supported the hypothesis that DSCT neurons primarily relay the activity of hindlimb afferents during locomotion, but lack input from the spinal central pattern generator (CPG). The VSCT neurons, on the other hand, were found to be active during actual locomotion (on a treadmill) even after de-afferentation, as well as during fictive locomotion (without phasic afferent feedback). In this study we compared the activity of DSCT and VSCT neurons during fictive rhythmic motor behaviors. We used decerebrate cat preparations in which fictive motor tasks can be evoked while the animal is paralyzed and there is no rhythmic sensory input from hindlimb nerves. Spinocerebellar tract cells with cell bodies located in the lumbar segments were identified by electrophysiological techniques and examined by extra- and intracellular microelectrode recordings. During fictive locomotion 57/81 DSCT and 30/30 VSCT neurons showed phasic, cycle-related activity. During fictive scratch 19/29 DSCT neurons showed activity related to the scratch cycle. We provide evidence for the first time that locomotor and scratch drive potentials are present not only in VSCT but also in the majority of DSCT neurons. These results demonstrate that both spinocerebellar tracts receive input from the CPG circuitry often sufficient to elicit firing in the absence of sensory input.
Authors:
Brent Fedirchuk; Katinka Stecina; Kasper Kyhl Kristensen; Mengliang Zhang; Claire Francesca Meehan; David J Bennett; Hans Hultborn
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-24
Journal Detail:
Title:  Journal of neurophysiology     Volume:  -     ISSN:  1522-1598     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1University of Manitoba.
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