Document Detail

Rhodotorula mucilaginosa outbreak in neonatal intensive care unit: microbiological features, clinical presentation, and analysis of related variables.
MedLine Citation:
PMID:  16525775     Owner:  NLM     Status:  MEDLINE    
Reported here are the features of a Rhodotorula mucilaginosa outbreak that occurred in a neonatal intensive care unit. Over a period of 19 days, clinical and laboratory signs of sepsis appeared in four premature infants carrying indwelling vascular catheters. After bloodstream infection with R. mucilaginosa was ascertained, the patients underwent amphotericin B therapy and recovered completely. In a retrospective case-control study, the variables displaying a statistical difference between case and control-group neonates were birth weight, gestational age, duration of parenteral nutrition, duration of antibiotic therapy and prophylactic administration of fluconazole. To our knowledge, this is the first reported outbreak caused by yeasts of the Rhodotorula genus.
R Perniola; M L Faneschi; E Manso; M Pizzolante; A Rizzo; A Sticchi Damiani; R Longo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  25     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-17     Completed Date:  2006-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
Neonatal Intensive Care Unit, V. Fazzi Regional Hospital, Piazza F. Muratore, 73100 Lecce, Italy.
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MeSH Terms
Amphotericin B / therapeutic use
Antifungal Agents / therapeutic use
Bacteremia / drug therapy,  epidemiology*,  microbiology
Case-Control Studies
Catheterization, Central Venous / adverse effects
Catheters, Indwelling / adverse effects
Disease Outbreaks*
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / drug therapy,  epidemiology*,  microbiology
Intensive Care Units, Neonatal*
Mycoses / drug therapy,  epidemiology*,  microbiology
Rhodotorula / isolation & purification*,  pathogenicity
Reg. No./Substance:
0/Antifungal Agents; 1397-89-3/Amphotericin B

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