Document Detail

Rhodium and iridium salts inhibit proliferation and induce DNA damage in rat fibroblasts in vitro.
MedLine Citation:
PMID:  22521858     Owner:  NLM     Status:  Publisher    
Environmental concentration of the platinum group elements is increased in the last years due to their use in automobile catalytic converters. Limited data are available on the effects of such elements at a cellular level and on their toxicity, especially for rhodium and iridium which have been more recently introduced in use. The toxic effects of rhodium and iridium salts were analyzed on a normal diploid rat fibroblast cell line in vitro. Both salts halted cell growth in a dose- and time-dependent fashion by inhibiting cell cycle progression, inducing apoptosis and modulating the expression of cell cycle regulatory proteins. In fact, they both caused an accumulation of cells in the G2/M phase of the cell cycle and affected the expression levels of pRb, cyclins D1 and E, p21(Waf1) and p27(Kip1). DNA strand breaks, as assessed by comet test, and an increase in the intracellular levels of reactive oxygen species also occurred in exposed cell cultures. These findings suggest a potential toxicity of both iridium and rhodium salts and emphasize the need for further studies to understand their effects at a cellular level to enable a better assessment of their toxic effects and to identify ways for their modulation and/or prevention.
Ivo Iavicoli; Valerio Cufino; Maddalena Corbi; Martina Goracci; Emanuele Caredda; Achille Cittadini; Antonio Bergamaschi; Alessandro Sgambato
Related Documents :
22415928 - Human embryonic stem cells exhibit increased propensity to differentiate during the g1 ...
17563758 - Planar cell polarity: one or two pathways?
18957258 - The formation and function of the female reproductive tract in flowering plants.
19580408 - Commercial development of cell-based therapeutics: strategic considerations along the d...
19048368 - Mcp-1-induced migration of nt2 neuroprogenitor cells involving app signaling.
2715008 - Monoclonal antibody internalization by tumor cells: an experimental model for potential...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-13
Journal Detail:
Title:  Toxicology in vitro : an international journal published in association with BIBRA     Volume:  -     ISSN:  1879-3177     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712158     Medline TA:  Toxicol In Vitro     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Institute of Occupational Medicine, "Giovanni XXIII" Cancer Research Center, Catholic University of Sacred Heart, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Treatment of acromegaly: A critical analysis of the last ten years.
Next Document:  Role of bovine adrenal medulla 22 (BAM22) in the pathogenesis of neuropathic pain in rats with spina...