Document Detail


RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/Rho-kinase/myosin phosphatase target pathway.
MedLine Citation:
PMID:  22829315     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: RhoE was frequently down-regulated in predominantly HBV-associated HCCs and this down-regulation was associated with a more aggressive HCC phenotype. RhoE regulated the cytoskeleton remodeling and suppressed HCC motility and invasiveness by way of inhibiting the Rho/ROCK axis.
Authors:
Wei Ma; Carmen Chak-Lui Wong; Edmund Kwok-Kwan Tung; Chun Ming Wong; Irene Oi-Lin Ng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  57     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-03-04     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Affiliation:
State Key Laboratory for Liver Research, University of Hong Kong, Hong Kong.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Animals
Carcinoma, Hepatocellular / enzymology*
Cell Line, Tumor
Cell Membrane / physiology
Cell Movement
Disease-Free Survival
Down-Regulation
Female
Gene Knockdown Techniques
Humans
Liver Neoplasms / enzymology*
Male
Mice
Mice, Nude
Middle Aged
Myosin-Light-Chain Phosphatase / metabolism*
Neoplasm Invasiveness
Phosphorylation
Signal Transduction
Stress Fibers / physiology
rho GTP-Binding Proteins / metabolism*
rho-Associated Kinases / metabolism*
Chemical
Reg. No./Substance:
EC 2.7.11.1/rho-Associated Kinases; EC 3.1.3.53/Myosin-Light-Chain Phosphatase; EC 3.6.5.2/RND3 protein, human; EC 3.6.5.2/rho GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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