Document Detail


Rho GTPases in platelet function.
MedLine Citation:
PMID:  23121917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Rho family of GTP binding proteins, also commonly referred to as the Rho GTPases, are master regulators of the platelet cytoskeleton and platelet function. These low-molecular-weight or 'small' GTPases act as signaling switches in the spatial and temporal transduction, and amplification of signals from platelet cell surface receptors to the intracellular signaling pathways that drive platelet function. The Rho GTPase family members RhoA, Cdc42 and Rac1 have emerged as key regulators in the dynamics of the actin cytoskeleton in platelets and play key roles in platelet aggregation, secretion, spreading and thrombus formation. Rho GTPase regulators, including GEFs and GAPs and downstream effectors, such as the WASPs, formins and PAKs, may also regulate platelet activation and function. In this review, we provide an overview of Rho GTPase signaling in platelet physiology. Previous studies of Rho GTPases and platelets have had a shared history, as platelets have served as an ideal, non-transformed cellular model to characterize Rho function. Likewise, recent studies of the cell biology of Rho GTPase family members have helped to build an understanding of the molecular regulation of platelet function and will continue to do so through the further characterization of Rho GTPases as well as Rho GAPs, GEFs, RhoGDIs and Rho effectors in actin reorganization and other Rho-driven cellular processes.
Authors:
J E Aslan; O J T McCarty
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  11     ISSN:  1538-7836     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-07-26     Revised Date:  2014-02-21    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-46     Citation Subset:  IM    
Copyright Information:
© 2012 International Society on Thrombosis and Haemostasis.
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MeSH Terms
Descriptor/Qualifier:
Actin Cytoskeleton / enzymology
Animals
Blood Platelets / enzymology*
Cell Shape
GTPase-Activating Proteins / blood
Guanine Nucleotide Exchange Factors / blood
Humans
Platelet Activation*
Pseudopodia / enzymology
Signal Transduction
Thrombosis / blood,  enzymology*
cdc42 GTP-Binding Protein / blood
p21-Activated Kinases / blood
rac GTP-Binding Proteins / blood
rho GTP-Binding Proteins / blood*
rho-Specific Guanine Nucleotide Dissociation Inhibitors / blood
rhoA GTP-Binding Protein / blood
Grant Support
ID/Acronym/Agency:
R01 HL101972/HL/NHLBI NIH HHS; R01-HL101972/HL/NHLBI NIH HHS; T32-HL007781/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/GTPase-Activating Proteins; 0/Guanine Nucleotide Exchange Factors; 0/rho-Specific Guanine Nucleotide Dissociation Inhibitors; EC 2.7.11.1/p21-Activated Kinases; EC 3.6.5.2/cdc42 GTP-Binding Protein; EC 3.6.5.2/rac GTP-Binding Proteins; EC 3.6.5.2/rho GTP-Binding Proteins; EC 3.6.5.2/rhoA GTP-Binding Protein
Comments/Corrections
Erratum In:
J Thromb Haemost. 2013 Jun;11(6):1209

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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