Document Detail


Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing.
MedLine Citation:
PMID:  20184864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis. Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound. The three GTPases are also required for actin cable formation at the wound leading edge. Rac1, Cdc42, and Rho1 act upstream of c-Jun N-terminal kinase (JNK) to organize actin assembly. These results highlight the similarities between the molecular mechanism of Drosophila wound healing and those of Drosophila embryonic dorsal closure and the chemotactic response of Dictyostelium and leukocytes.
Authors:
Seung Hee Baek; Young-Chang Kwon; Hyangkyu Lee; Kwang-Min Choe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-23
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  394     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  488-92     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Biology, Yonsei University, 262 Seongsanno, Seodaemun-gu, Seoul 120-749, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Animals
Cell Polarity*
Drosophila Proteins / genetics,  physiology*
Drosophila melanogaster / enzymology,  physiology*
JNK Mitogen-Activated Protein Kinases / metabolism
Myosins / metabolism
Wound Healing*
cdc42 GTP-Binding Protein / genetics,  physiology*
rac GTP-Binding Proteins / genetics,  physiology*
rho GTP-Binding Proteins / genetics,  physiology*
Chemical
Reg. No./Substance:
0/Actins; 0/Drosophila Proteins; 0/Rac1 protein, Drosophila; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases; EC 3.6.4.1/Myosins; EC 3.6.5.2/Rho1 protein, Drosophila; EC 3.6.5.2/cdc42 GTP-Binding Protein; EC 3.6.5.2/rac GTP-Binding Proteins; EC 3.6.5.2/rho GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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