Document Detail

Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing.
MedLine Citation:
PMID:  20184864     Owner:  NLM     Status:  MEDLINE    
A wound induces cell polarization, in which myosin II is localized at the rear end of individual cells in a migrating epithelial sheet of the Drosophila larval epidermis. Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound. The three GTPases are also required for actin cable formation at the wound leading edge. Rac1, Cdc42, and Rho1 act upstream of c-Jun N-terminal kinase (JNK) to organize actin assembly. These results highlight the similarities between the molecular mechanism of Drosophila wound healing and those of Drosophila embryonic dorsal closure and the chemotactic response of Dictyostelium and leukocytes.
Seung Hee Baek; Young-Chang Kwon; Hyangkyu Lee; Kwang-Min Choe
Related Documents :
16650994 - Tiam1 takes part in cell polarity.
22314054 - O-glcnacase is essential for embryonic development and maintenance of genomic stability.
22682874 - Sensor and effector kinases in dna damage checkpoint regulate capacity for homologous r...
20875404 - Function of liprins in cell motility.
10569204 - Early events in the formation of a tissue structure from dispersed bovine adrenocortica...
20083214 - The role of centrosomes in fertilization, cell division and establishment of asymmetry ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-23
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  394     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  488-92     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Biology, Yonsei University, 262 Seongsanno, Seodaemun-gu, Seoul 120-749, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Actins / metabolism
Cell Polarity*
Drosophila Proteins / genetics,  physiology*
Drosophila melanogaster / enzymology,  physiology*
JNK Mitogen-Activated Protein Kinases / metabolism
Myosins / metabolism
Wound Healing*
cdc42 GTP-Binding Protein / genetics,  physiology*
rac GTP-Binding Proteins / genetics,  physiology*
rho GTP-Binding Proteins / genetics,  physiology*
Reg. No./Substance:
0/Actins; 0/Drosophila Proteins; 0/Rac1 protein, Drosophila; EC Mitogen-Activated Protein Kinases; EC; EC protein, Drosophila; EC GTP-Binding Protein; EC GTP-Binding Proteins; EC GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A new property of twitchin to restrict the "rolling" of mussel tropomyosin and decreases its affinit...
Next Document:  Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family protei...