Document Detail

Rho GTPases in pulmonary vascular dysfunction.
MedLine Citation:
PMID:  22982942     Owner:  NLM     Status:  Publisher    
Rho proteins, best known for their regulatory role in actin dynamics, stimulate a variety of processes important in the control of vascular function, including morphogenesis, migration, cell proliferation and adhesion, cell survival, gene expression, vesicle transport and microparticle formation. Rho GTPases have been implicated in several pulmonary vascular pathologies. Here we give an overview of the current knowledge of the role of Rho GTPases in vascular dysfunction, and pulmonary diseases such as pulmonary hypertension, pulmonary embolism chronic obstructive pulmonary disease, acute lung injury and acute respiratory distress syndrome.
Elisabeth M Storck; Beata Wojciak-Stothard
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-13
Journal Detail:
Title:  Vascular pharmacology     Volume:  -     ISSN:  1879-3649     ISO Abbreviation:  Vascul. Pharmacol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130615     Medline TA:  Vascul Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Centre for Pharmacology & Therapeutics, Imperial College London; Department of Chemistry, Imperial College London, London, UK.
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