| Rho GTPases in pulmonary vascular dysfunction. | |
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MedLine Citation:
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PMID: 22982942 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Rho proteins, best known for their regulatory role in actin dynamics, stimulate a variety of processes important in the control of vascular function, including morphogenesis, migration, cell proliferation and adhesion, cell survival, gene expression, vesicle transport and microparticle formation. Rho GTPases have been implicated in several pulmonary vascular pathologies. Here we give an overview of the current knowledge of the role of Rho GTPases in vascular dysfunction, and pulmonary diseases such as pulmonary hypertension, pulmonary embolism chronic obstructive pulmonary disease, acute lung injury and acute respiratory distress syndrome. |
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Authors:
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Elisabeth M Storck; Beata Wojciak-Stothard |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-13 |
Journal Detail:
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Title: Vascular pharmacology Volume: - ISSN: 1879-3649 ISO Abbreviation: Vascul. Pharmacol. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130615 Medline TA: Vascul Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
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Centre for Pharmacology & Therapeutics, Imperial College London; Department of Chemistry, Imperial College London, London, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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