| Rhinologic symptoms and quality-of-life in patients with Churg-Strauss syndrome vasculitis. | |
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MedLine Citation:
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PMID: 18702907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The purpose of this study was to investigate the presentation pattern, sinonasal symptoms, and quality of life (QOL) in patients with Churg-Strauss syndrome (CSS) vasculitis. METHODS: A cross-sectional study was performed. Twenty-five patients with CSS belonging to a patient self-help group participated. Main outcome measures included mode of initial presentation, treatment, rhinologic symptoms, and disease-specific QOL (Sinonasal Outcome Test [SNOT-22] scores) and comparisons were made with general rhinosinusitis and other nasally affected vasculitis patients (Wegener's granulomatosis [WG]). RESULTS: Overall, 80% of CSS patients had active sinonasal symptoms at the time of the study. Twenty-eight percent of CSS patients reported worsening of their nasal symptoms as the main event leading to their diagnosis. Forty-eight percent of CSS patients had undergone nasal surgery. Nasal symptoms that are of particular relevance to this patient group are nasal obstruction (95%), rhinorrhea (95%), anosmia (90%), and excessive sneezing (80%). Other symptoms included nasal crusting (75%), purulent nasal discharge (65%), and epistaxis (60%). SNOT-22 scores were significantly higher than normal, reaching average values similar to those of patients from the general rhinosinusitis population. CONCLUSION: Sinonasal symptoms are common at initial presentation of CSS, emphasizing the role of otolaryngologists in its diagnosis. Overall, CSS-related sinonasal morbidity is significant and comparable with that of the general rhinosinusitis population. It predominantly results from symptoms of allergic rhinitis, but a significant proportion of CSS patients also report milder forms of crusting, epistaxis, and of purulent sinusitis, symptoms which are more commonly attributed to patients with WG. |
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Authors:
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Ibrahim Srouji; Valerie Lund; Peter Andrews; Chris Edwards |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of rhinology Volume: 22 ISSN: 1050-6586 ISO Abbreviation: Am J Rhinol Publication Date: 2008 Jul-Aug |
Date Detail:
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Created Date: 2008-08-15 Completed Date: 2008-10-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807268 Medline TA: Am J Rhinol Country: United States |
Other Details:
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Languages: eng Pagination: 406-9 Citation Subset: IM |
Affiliation:
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Ipswich Hospital, Ipswich, Suffolk, United Kingdom. ibs@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Chronic Disease Churg-Strauss Syndrome / complications*, drug therapy, psychology Cross-Sectional Studies Female Great Britain / epidemiology Humans Immunosuppressive Agents / therapeutic use Incidence Male Middle Aged Quality of Life* Rhinitis / complications*, epidemiology, psychology Sinusitis / complications*, psychology |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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