Document Detail


Rhinologic and sinonasal changes in PR3 ANCA pulmonary vasculitis.
MedLine Citation:
PMID:  21147659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Over 70-95% patients with PR3 ANCA pulmonary vasculitis present with upper respiratory tract symptoms or sings. Nasal cavity usually presents with obstruction and chronic refractory infections (rhinosinusitis) which commonly manifest as bloody discharge or crusting obstruction. Mucopurulent discharge may occur in the acute phase or remission, along with other symptoms suggesting sinusitis. Later on, saddle nose deformities can occur due to collapse of the nasal septum. Other common destruction areas are the maxillary ostia, erosion of the tubinates or damage of soft palate.
OBJECTIVE: The aim of the study was to characterize pathologies of nasal and sinonasal CT scans in patients with PR3 pulmonary ANCA vasculitis and to establish the CT diagnostic criteria for WG. Between 2005-2009 sinonasal CT visualization was performed in 35 patients (19 female, 16 male) with PR3 ANCA positive WG.
RESULTS: Bony destruction of the nasal cavity was revealed in 15 (42.8%), damage or distortion of the paranasal sinuses in 20 (57.1%), the mastoid cells in 7 (20%), and the orbits in 7 (20%) patients. Sclerosing osteitis of the nasal cavity and paranasal sinuses were observed in 11 (31.4%) and in 24 (68.5%), respectively. Bony thickening of the nasal cavity was shown in 5 (14.2%) patients and of the paranasal sinuses in 7 (20%) (unilateral in 2 and bilateral in 5 patients). Seven patients (20%) had orbital masses; all unilateral. Septal perforation was observed in 11 (31.4%) and saddle nose deformity in 7 (20%) patients.
CONCLUSIONS: Maxillary sinuses are regions which are most frequently affected during the course of PR3 ANCA pulmonary vasculitis. CT imagines may be a useful supplement to clinical and activity scoring of WG disease with pulmonary involvement.
Authors:
Katarzyna Zycinska; K A Wardyn; E Piotrowska; T M Zielonka; H Zycinski; A Bogaczewicz; A Nitsch-Osuch; M Miskiewicz; R Smolarczyk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of medical research     Volume:  15 Suppl 2     ISSN:  0949-2321     ISO Abbreviation:  Eur. J. Med. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-02-25     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9517857     Medline TA:  Eur J Med Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  241-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Antineutrophil Cytoplasmic / analysis*
Female
Humans
Male
Middle Aged
Nasal Cavity / pathology*
Paranasal Sinuses / pathology*
Retrospective Studies
Tomography, X-Ray Computed
Wegener Granulomatosis / pathology*
Chemical
Reg. No./Substance:
0/Antibodies, Antineutrophil Cytoplasmic

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